Industry Insights

  1. Let The Molecule Decide

    Formulation techniques and technologies can easily become more habit than science, but a single technology does not work for all compounds. Each new drug is unique and deserves a fresh approach to formulation.

  2. Keeping Your Cool When Storing Purified Protein

    The study of proteins and their function is central to understanding biology, but separating and purifying single proteins from complex mixtures is hard work. After investing the time to purify your target protein using various chromatography methods, losing your protein integrity because of improper storage would be devastating. Good storage conditions are particularly important if you need your protein for several downstream studies. You might need to store your preparation for an extended period of time, and some experiments require that the protein retain its original structure, binding affinity or enzymatic activity. Here we discuss some quick and simple suggestions relating to concentration, additives, sample size and storage temperature to consider when storing your protein for future use.

  3. Tips For Preparing Process-Scale Chromatography Columns

    caling up from laboratory-scale to process-scale purification is one of the most important manufacturing activities for the pharmaceutical industry. However, many challenges exist in this activity.

  4. Cost And Impact Of A Bioburden Incident

    Manufacturing biologicals is tricky. A major concern is the risk of microbial contamination, jeopardizing product safety and causing high costs. But there are solutions for decreasing the risks.

  5. Keys To Successful Technology Transfers

    The choice of potential technology transfer partners can be bewildering. This article shares some of the factors that should be taken into account when making this decision.

  6. Impact Of Incorrect Forecasts On New Drug Product Launches

    In today’s drug manufacturing environment, demand forecasts provide critical input that ultimately affects pharmaceutical companies’ decision-making processes.

  7. Selecting The Optimal Resins For mAb Process Purification

    The development of monoclonal antibody (mAb) technology over the past 25 years has fundamentally changed the questions we ask and led to many innovative discoveries. These highly specific biological products have significantly influenced the direction and progress of research and therapeutics.

  8. Utility Of GMP Next-Generation Sequencing (NGS) For Biosafety Assessment Of Biological Products

    By delivering significantly more data than traditional Sanger-based sequencing methods, NGS opens a range of possibilities for the analysis of diverse DNA and RNA populations.

  9. The Key To Unlocking Foreign Pharmaceutical Markets

    The opportunities in developing global markets appear limitless, but the obstacles surrounding them can be daunting. With issues ranging from language barriers to protecting intellectual property rights, each solution must be as unique as the country the work is developed in. Download this eBook to learn key strategies to unlock foreign pharma markets.

  10. Characterizing Drug Substance Properties Early Can Optimize Drug Product Formulation

    Molecules continue to get more challenging from the perspective of solubility, bioavailability, and exposure. Advances in formulation technologies continue to provide more solutions. Establishing effective communications between DS chemists and DP formulators manage the risks and maximize the rewards of transforming less soluble and less bioavailable molecules into effective new drugs.