Expert Insights On Upstream Bioprocessing

1. TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration 12/8/2025

   When configured correctly, TFF provides the gentle processing environment and oxygen protection required for strict anaerobes.

2. Strained Manufacturing, Complexity Stymie In Vivo Progress 12/4/2025

    Explicitly mapping delivery challenges to the associated GMP process steps converts biological risk into operational risk.

3. An End-To-End Automated HTP Platform For Cell Line Optimization 11/20/2025

   Bristol Myers Squibb's high-throughput stable CHO platform produces high-titer, high-quality material in a fraction of the conventional timeline.

4. Solving The Stem Cell Consistency Conundrum With iMSCs 11/17/2025

   The ability to produce unlimited batches of induced mesenchymal stem cells from a single iPSC cell bank is, perhaps, one of their most alluring features.

5. Sensitive Critical Starting Materials Need A 'Just-In-Data' Approach 11/14/2025

   Here's a blueprint for transforming the fragmented, high-risk interface between vector and cell therapy platforms into a unified, predictable, and compliant system.

6. Exploring The Benefits Of Electroporation In NK Cell Transfection 11/14/2025

   Electroporation creates temporary holes in cell membranes for genetic material to slip through. The technique offers some key advantages to viral transduction.

7. A Multi-Omics Approach For Characterizing Clinical-Scale iPSC Batches 11/6/2025

   The transition from 2D to 3D cell culture requires a combination of advanced analytical techniques, but aligning new methods with established principles can be challenging.

8. Here's A Thought: What If Gene Editing Didn't Use Bacterial Enzymes? 10/27/2025

   Citing the dismally few wins for CRISPR/Cas9 and other gene editing systems, one scientist proposes delivering zinc finger DNA-binding peptides using AAV6 vectors.

9. Analyzing CAR-T Surface Proteins With Immunoprecipitation Coupled With Mass Spectrometry 10/24/2025

   Among other benefits, the approach can help compare CAR constructs, evaluate the effects of manufacturing processes, and monitor changes in protein interactions.

10. How Sethera Harnesses A Promiscuous Enzyme To Make Recombinant Peptides 10/21/2025

    A class of enzymes previously believed to be specific and intolerant of change might actually have broad applicability.