Downstream Isolation and Purification

1. Expanding Manufacturing Of Purification Resins To Align With Customer Demands 7/15/2025

   Discover how scaling up processes and building out facilities has allowed for end-to-end solutions that meet customer requirements for both supply and quality in their production lines.

2. MilliporeSigma Large Scale Capabilities Tour 10/20/2021

   A detailed look at MilliporeSigma’s new BioReliance® viral vector manufacturing facility and how we have employed the latest innovations and quality systems to deliver best-in-class gene therapy services.

3. A Scalable Immobilized Metal Affinity Chromatography Media For Process Purification 5/6/2021

   Downstream process purification of proteins requires a resin with optimized bead size for ideal pressure/flow properties and decent dynamic binding capacity DBC that provides production efficiencies and good process economics. This video explains how our newly developed metal chelate affinity resin — Nuvia IMAC — provides the mechanical strength, pore structures, ligand density, and particle size distribution required for an operation run at 300 cm/hr with a DBC of 40 mg/ml at 2 bar column backpressure.

4. Purification Strategies For Multispecifics 6/2/2025

   In this segment from the Bioprocess Online Live event, “Challenges And Considerations For Purifying Multispecific Molecules,” our panelists Mark Fitchmun and Dr. Jian Ren debate the use of affinity resins compared to ion exchange and multimodal chromatography methods.

5. What Is The DynaChrom™ Single-Use Chromatography System? 3/21/2024

   This chromatography system offers a flexible solution, paired with an advanced software platform, allowing easy integration with downstream process automation.

6. Downstream Purification Symposium Overview 7/13/2018

   A focus on strategies for virus and monoclonal antibody purification, viral clearance, and aggregate removal challenges

7. Your Roadmap For Efficient Processes 3/4/2025

   Struggling with mRNA integrity? Discover essential strategies to boost stability in mRNA manufacturing with innovative endonuclease-free DTT and Spermidine chemicals.

8. Overview Of DoE Workshop At Bio-Rad 7/13/2018

   This video reviews a DoE Workshop that provided best practices and guidelines for DOE experiments using mixed-mode chromatography resins.

9. High Capacity, Scalable Cation Exchange Chromatography Membrane For Purification Of Monoclonal Antibody 11/11/2025

   Overcome binding capacity limitations in mAb purification. A new hydrogel membrane enhances productivity 30x over resins, offering superior loading capacity and consistent, scalable impurity removal.

10. Redefine Your Oligonucleotide Manufacturing 4/22/2025

    Streamline oligo production and scale confidently. Explore high-performing, purpose-built automated equipment designed to ensure safety, efficiency, and purity, from synthesis through concentration.