Downstream Isolation and Purification

1. Robust Workflow For Single Cell Cloning Of iPSCs For Making cGMP Master Cell Banks 3/7/2022

   We demonstrate a platform combination of Solentim instrumentation (the VIPS™) and soluble matrix (MatriClone™, based on laminin) for the high-efficiency, high-viability single-cell cloning of iPSCs to form the Master Cell Bank.

2. A Scalable Immobilized Metal Affinity Chromatography Media For Process Purification 5/6/2021

   Downstream process purification of proteins requires a resin with optimized bead size for ideal pressure/flow properties and decent dynamic binding capacity DBC that provides production efficiencies and good process economics. This video explains how our newly developed metal chelate affinity resin — Nuvia IMAC — provides the mechanical strength, pore structures, ligand density, and particle size distribution required for an operation run at 300 cm/hr with a DBC of 40 mg/ml at 2 bar column backpressure.

3. What Is The DynaChrom™ Single-Use Chromatography System? 3/21/2024

   This chromatography system offers a flexible solution, paired with an advanced software platform, allowing easy integration with downstream process automation.

4. Meet The Experts: Part 1 - Process Analytical Technology (PAT) 5/1/2023

   Watch part 1 of this 4-part interview series to learn about process analytical technology (PAT) from expert Stacy Shollenberger.

5. A Conceptual Overview Of The BioSMB MCC Platform 6/7/2021

   In this video, our technology expert Jason Forte describes how the BioSMB system offers 3-5 fold increase in productivity, yielding up to 80% savings on chromatography resin costs with minimal disruption to the accepted ways of doing chromatography today.

6. Chromatography Support Solutions 7/13/2018

   This video highlights Bio-Rad services including the development and optimization of purification platforms to meet today's manufacturing demands.

7. Explore Selectivity With Eshmuno® CMX Chromatography Resin 6/19/2020

   Eshmuno® CMX chromatography resin is a highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins.

8. Navigating The Diverse Antibody Pipeline With Chromatography Innovations 5/23/2022

   Choosing a suitable resin for your purification needs doesn’t have to be daunting. Learn more about how to select the right resin for your antibody variant purification project.

9. Eshmuno® CMX ADC Polishing Animation 7/16/2020

   This animation demonstrates how Eshmuno® CMX Chromatography Resin removes undesired low DAR and high DAR species, enabling the best pharmacokinetics, efficacy, half-life and tolerability.

10. MilliporeSigma Large Scale Capabilities Tour 10/20/2021

    A detailed look at MilliporeSigma’s new BioReliance® viral vector manufacturing facility and how we have employed the latest innovations and quality systems to deliver best-in-class gene therapy services.