Downstream Isolation and Purification

  1. A Scalable Immobilized Metal Affinity Chromatography Media For Process Purification 5/6/2021

    Downstream process purification of proteins requires a resin with optimized bead size for ideal pressure/flow properties and decent dynamic binding capacity DBC that provides production efficiencies and good process economics. This video explains how our newly developed metal chelate affinity resin — Nuvia IMAC — provides the mechanical strength, pore structures, ligand density, and particle size distribution required for an operation run at 300 cm/hr with a DBC of 40 mg/ml at 2 bar column backpressure.

  2. What Makes A High-Quality Chromatography Resin? 9/26/2022

    The demand for resins for the manufacture of biological medicines is increasing every year. Walk through the process of what makes a high-quality chromatography resin.

  3. Redefine Your Oligonucleotide Manufacturing 4/22/2025

    Streamline oligo production and scale confidently. Explore high-performing, purpose-built automated equipment designed to ensure safety, efficiency, and purity, from synthesis through concentration.

  4. Optimized Purity Of A Monoclonal Antibody, Carsten Voß Video 4/12/2016

    Purity, recovery, and elution volume are important factors and parameters when screening multiple media (resins) for the development of efficient, robust, and economical production processes.

  5. MilliporeSigma Large Scale Capabilities Tour 10/20/2021

    A detailed look at MilliporeSigma’s new BioReliance® viral vector manufacturing facility and how we have employed the latest innovations and quality systems to deliver best-in-class gene therapy services.

  6. Downstream Purification Symposium Overview 7/13/2018

    A focus on strategies for virus and monoclonal antibody purification, viral clearance, and aggregate removal challenges

  7. A Conceptual Overview Of The BioSMB MCC Platform 6/7/2021

    In this video, our technology expert Jason Forte describes how the BioSMB system offers 3-5 fold increase in productivity, yielding up to 80% savings on chromatography resin costs with minimal disruption to the accepted ways of doing chromatography today.

  8. Eshmuno® CMX ADC Polishing Animation 7/16/2020

    This animation demonstrates how Eshmuno® CMX Chromatography Resin removes undesired low DAR and high DAR species, enabling the best pharmacokinetics, efficacy, half-life and tolerability.

  9. Overview Of DoE Workshop At Bio-Rad 7/13/2018

    This video reviews a DoE Workshop that provided best practices and guidelines for DOE experiments using mixed-mode chromatography resins.

  10. Chromatography Support Solutions 7/13/2018

    This video highlights Bio-Rad services including the development and optimization of purification platforms to meet today's manufacturing demands.