Downstream Isolation and Purification

  1. Poster Review Non–Affinity Based Purification Platform for Neutral/Basic IgMs 9/21/2018

    Review the biological properties of IgM antibodies that make them very effective vehicles for in vitro diagnostics and therapeutics.

  2. Challenges And Opportunities For Improved Chromatography Resins 6/11/2018

    Professor Giorgio Carta from the Department of Chemical Engineering at the University of Virginia gives an overview of recent advances in the development of resins for protein purification and in understanding protein-surface interactions that are responsible for separation.

  3. Intensified Virus Purification: Better, Faster, Virus Production 5/21/2020

    Viruses are widely used in many vaccines and therapies. Despite the difference in application there are similar process challenges. Learn how to overcome those challenges in this video.

  4. Optimized Purity Of A Monoclonal Antibody, Carsten Voß Video 4/12/2016

    Purity, recovery, and elution volume are important factors and parameters when screening multiple media (resins) for the development of efficient, robust, and economical production processes.

  5. Perform Multiple Chromatography Steps On A Single System 2/26/2024

    The Resolute® BioSC platform is a highly modular multi-step chromatography system designed to purify biologics. The platform can be configured to design your own multi-step process.

  6. Resolute® BioSMB Multi-Column Chromatography 12/2/2024

    Learn how to achieve better resin utilization, minimize disruption to existing methods, and align your strategy with unique process goals.

  7. Single-Use Centrifuge Cinematic 10/24/2022

    Gain a 360° view of the Thermo Scientific™ DynaSpin™ Single-Use Centrifuge.

  8. Navigating The Diverse Antibody Pipeline With Chromatography Innovations 5/23/2022

    Choosing a suitable resin for your purification needs doesn’t have to be daunting. Learn more about how to select the right resin for your antibody variant purification project.

  9. Droplet Digital PCR Systems 9/21/2018

    Droplet Digital PCR (ddPCR) simplifies the quantification of host cell DNA in process development, quality control, and biomanufacturing processes.

  10. A Scalable Immobilized Metal Affinity Chromatography Media For Process Purification 5/6/2021

    Downstream process purification of proteins requires a resin with optimized bead size for ideal pressure/flow properties and decent dynamic binding capacity DBC that provides production efficiencies and good process economics. This video explains how our newly developed metal chelate affinity resin — Nuvia IMAC — provides the mechanical strength, pore structures, ligand density, and particle size distribution required for an operation run at 300 cm/hr with a DBC of 40 mg/ml at 2 bar column backpressure.