FEATURED ARTICLES

• Evaluating CAR T-Cell Therapy Vascular Recruitment, Trafficking, And Killing

  Learn about a more human-relevant platform that enables researchers to assess the trafficking and killing efficiency of immunotherapy as well as the proof-of-concept of immuno-oncology co-therapy.

• Studying Gut Inflammation And Barrier Disruption With Organ-On-A-Chip Technology

  See how the Colon Intestine-Chip has been employed to model cytokine-mediated inflammation and barrier disruption in the intestine.

• Recapitulating Inflammation: How To Use the Colon Intestine-Chip To Study Complex Mechanisms Of IBD

  To address the challenges associated with conventional drug development models, a Colon Intestine-Chip has been developed to recapitulate the biology that drives inflammatory bowel disease.

• Predicting Human Liver Damage With A More Accurate In Vitro Hepatotoxicity Assay

  This study explores whether a species-specific, multicellular, in vitro hepatotoxicity assays utilizing Liver-Chips can provide a greater understanding of hepatotoxicity mechanisms than animal models.

• Investigating Key Mechanisms Of Parkinson’s With A Novel Model

  Efforts to develop a dynamic “brain-on-a-chip” model that closely resembles the human substantia nigra could be applied to study mechanisms of Parkinson’s disease.

• Creating A Shigella Infection Model Using Organs-On-Chips

  Learn how researchers have utilized Organs-on-Chips technology to test the infectivity of Shigella through several experimental approaches.

• Modeling Complex Human Immune Response In A Novel Intestine-Chip

  Learn about immune cell recruitment, why it is important when researching inflammatory bowel disease (IBD) and other diseases, how Organ-Chips benefit IBD research, and more.

• Developing More Clinically Relevant Drug-Induced Thrombosis Models

  Learn how this Blood Vessel-Chip is capable of replicating drug side effects and mimicking the human circulatory system accurately, enhancing drug safety and efficacy in development.

• Boosting In Vitro Toxicology Testing With Organ-Chips

  Discover how Organ-Chips are enhancing preclinical testing, minimizing toxicity issues, and streamlining clinical trials for enhanced safety and efficiency.

• Advancing 3D Cell Culture Models For Clinical Relevance

  Concerns about in vitro relevance and animal study limits have advanced cell culture tech. Explore how Organ-Chips offer a refined approach to studying human physiology.

• Organ-Chips: A Promising Model For Human Emulation

  Organ-Chips offer more accurate assessments of safety and efficacy readouts compared to other cell and animal models used by academia, government, and pharmaceutical entities to study drug toxicity.

• Advances In Developing In Vitro Models Of Neurodegenerative Diseases

  Discover a more predictive in vitro model of the human brain that represents the next step in predictive biological models for neurodegenerative disease research.

• A Better Immune Response To Vaccination: Using Lymphoid Follicle Organ-Chips

  Discover a first-of-its-kind human LF-Chip containing B, T, plasma and antigen-presenting cells to test functional immunization responses to vaccines and adjuvants in vitro.

• Creating An Effective Pre-Clinical Model Of Bone Marrow

  A Bone Marrow-Chip (BM-Chip) was created to recapitulate relevant hematopoietic cell types in a three-dimensional (3D), mechanically active next-generation in vitro model.

• The Technology Improving Inflammatory Disease Drug Development

  Learn about the global health burden of inflammatory disease, challenges associated with modeling inflammatory disease, and the future of inflammatory disease research.

• Revolutionizing Viral Infectious Disease Research And Drug Discovery

  Learn how Organ-Chips are being used to rapidly identify promising treatments, investigate virus evolution, and analyze how mechanical forces influence the innate immune response to viral infections.

• Proximal Tubule Kidney-Chip For Modeling Human Physiology

  Discover how an Organ-Chip can be used to create a comprehensive recapitulation of the proximal tubule, addressing the need for more human-relevant preclinical models in the pharmaceutical industry.

• Duodenum Intestine-Chip For Modeling Human Physiology

  Discover an Intestine-Chip that integrates the robust cell sourcing of organoids with Organs-on-Chips technology to overcome experimental limitations and yield a closer-to-human transcriptomic profile.

• Development And Characterization Of The Species-Specific Liver-Chip

  There is a growing need for more human-relevant preclinical models. Explore how Organ-Chips offer a viable solution and can be used to create a comprehensive recapitulation of the liver sinusoid.

• Characterization Of The Colon Intestine-Chip

  Learn about the development and characterization of Organ-Chips and what makes them the most comprehensive model of the colonic epithelial-endothelial interface that is commercially available.