Assessing Nephrotoxicity And Drug-Drug Interactions With The Emulate Proximal Tubule Kidney-Chip

During preclinical drug development, predicting drug-induced kidney toxicity and drug-drug interactions remains a challenge because of the reliance on immortalized cell lines and animal models that fail to accurately translate to human response. These translational challenges have significant clinical impacts, with nephrotoxicity contributing to preclinical attrition and leading to approximately 19% of phase 3 clinical trial failures.

The Emulate Proximal Tubule Kidney-Chip was created to address these issues, allowing researchers to more precisely model nephrotoxicity and drug interactions to enhance clinical success. This chip incorporates primary human kidney epithelial cells and tissue-specific endothelium within a dynamic microenvironment, resulting in a realistic kidney phenotype with normal epithelial cell polarity and morphology, as well as functional transporter activity relevant to in vivo conditions.

Watch this data-driven webinar to discover how Organ-on-a-Chip technology can help you overcome the limitations of traditional kidney models and increase your confidence before advancing your drug candidate to the clinic.