Newsletter | December 17, 2025

12.17.25 -- TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration

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Intensify your monoclonal antibody (mAb) production workflow:

Explore upstream and downstream strategies for mAb production with Gibco Efficient‑Pro Media and Feed System, ultra‑high‑density cell banks and DynaDrive single‑use bioreactors for seed train streamlining, and purification options including MabCaptureC Affinity Matrix and POROS Hydrophobic Interaction Chromatography (HIC) Resin in flow‑through mode. Download the application note to learn more about the mAb process intensification strategies.

FOCUS ON DOWNSTREAM MANUFACTURING

TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration

When configured correctly, TFF provides the gentle processing environment and oxygen protection required for strict anaerobes.

Methods For MSC Concentration And Buffer Exchange

Effective cell concentration and buffer exchange are crucial in MSC biomanufacturing for safety and efficacy. Compare the trade-offs of centrifugation, filtration, and elutriation to optimize your process.

Using Cation Exchange Chromatography For High-Yield Vaccine Production

Learn how to achieve high yields in vaccine production by using Cation Exchange Chromatography for purification. This method provides high purity and minimizes protein aggregates.

Turbocharging pDNA Production: CDMO Case Study In Optimization

Optimize your plasmid DNA workflows with insights from Forge Biologics. Discover how TFF advancements cut processing time by 300% while improving RNA removal and DNA quality.

Developing A Sterilizing Grade Filter For High Concentration Biologics

Explore an approach to developing a sterilizing-grade filter for high-concentration biologics that enabled extensive filterability trials to be conducted without needing a large quantity of product.

Cell Collection Basics For The Transplant And CGT Industries

Breakthroughs in CAR T-cell and stem cell therapies depend on mastering cellular collection. Understanding these fundamentals is vital for advancing treatment efficacy and patient outcomes.

Overcoming Downstream Challenges In Antibody Development

Unlock expert strategies for navigating the complex downstream purification and process challenges inherent in developing next-generation antibodies. Design for scalability from the start.

Novel Chromatography Solutions, Quality Testing For Vaccine Development

Learn more on novel chromatography solutions that can help improve the downstream processes of different vaccine types such as mRNA, recombinant proteins, and Virus-Like Particles (VLPs).

DOWNSTREAM MANUFACTURING SOLUTIONS

Automated, Single-Use Systems For TFF At Multiple Scales - Cytiva

Blast Freezing And Thawing For Any Primary Packaging - Single Use Support

Predicting CHO Retroviral Particle Clearance - Cygnus Technologies Inc.

GORE Protein Capture Devices With Protein A - W.L. Gore & Associates

FOCUS ON FILL-FINISH

mRNA Immunogenicity: Early Assessment Of Human Immune Response

Review strategies to assess the potential for human immune response following the administration of an mRNA therapeutic, the associated LNP, and the protein encoded for by the mRNA.

Switching From Vials To PFS And Intravenous To Subcutaneous Formulations

Learn about formulation development challenges for prefilled syringes as well as considerations for reducing the time it takes to launch safer, more convenient, and cost-effective products for the patient.

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