Turbocharging pDNA Production: CDMO Case Study In Optimization

As the demand for gene therapies continues to surge, the need for more efficient and scalable plasmid DNA manufacturing processes has become increasingly urgent. One of the most promising advancements in this space involves optimizing Tangential Flow Filtration (TFF), a technique that plays a critical role in plasmid purification. In a compelling case study, Forge Biologics partnered with Repligen to explore how strategic enhancements to TFF could revolutionize plasmid DNA production. Their collaboration led to a remarkable 300% reduction in processing time, significantly improved RNA removal, and maintained high levels of supercoiled DNA—an essential quality attribute for therapeutic applications.

Explore the full story and discover how you can apply these insights to optimize your own plasmid DNA workflows.