Newsletter | December 15, 2025

12.15.25 -- TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration

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Leveraging Platform Processes For Developing And Accelerating Novel Gene And Cancer Therapeutics

The FDA released its draft guidance for the Platform Technology Designation Program, a pivotal step forward for drug development. In this webinar we discover the advantages of platform processes for advancing novel gene therapies, the role of robust partnerships in ensuring patient access to curative treatments, and how these collaborative efforts are shaping the future of therapeutic development. Click here to watch now.

FOCUS ON UPSTREAM MANUFACTURING

TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration

When configured correctly, TFF provides the gentle processing environment and oxygen protection required for strict anaerobes.

Enabling 2-4x EV Yield Improvements In Bioreactor Culture

A new chemically defined fed-batch bioprocess medium simplifies hMSC-EV production, increasing yields while maintaining EV quality across donors and tissue types in scalable GMP-compatible environments.

Generate CHO-K1 GFP-Expressing Cells For Cell Line Development Workflow

Discover a high-efficiency workflow for generating GFP-expressing CHO-K1 clones using automated single-cell dispensing to achieve 93% isolation success and stable expression in under five weeks.

Optimize Your Advanced Therapy Manufacturing Before You Automate

Dive into specific unit operations and case studies that demonstrate how implementing phase appropriate tools can have substantive direct business impacts to cost and development timelines.

Mammalian Display Method For Enhanced Affinity TCR-Based Biologics

Learn how mammalian display enhances T cell receptor-based cancer therapies. This method improves antigen affinity and reduces immunogenicity for more effective treatments.

Enhancing Post-Electroporation Performance For Non-Viral Gene Editing

Non-viral gene editing is a powerful method for cell therapy. Learn how to address key challenges like cell viability and thermal damage with an innovative approach designed to improve performance.

CAR Expression Detection Using Fluorescent Labeled Proteins

Learn how site-specific fluorescent labeling addresses key challenges in flow cytometry-based evaluations by enhancing assay sensitivity, reducing variability, and ensuring reliable results.

Leveraging Transposase Technologies To Optimize Cell Line Development

Enable a wide array of genomic manipulation with the more regulated and efficient genomic insertion that's made possible by transposase-based technologies.

Mitigating Oxygen Heterogeneity In Large-Scale Bioreactors

Oxygen heterogeneity, caused by pressure variations and other factors in large-scale bioreactors, can significantly impact cell growth and product yield.

Linear Scale-Up Of hiPSC Cell Lines Using Vertical-Wheel Bioreactors

Explore how innovative bioreactor technology enables consistent and efficient scale-up of human induced pluripotent stem cells (hiPSCs) from 100ml to 3L, ensuring optimal cell yield and quality.

Redefining T Cell Culture Media

Media selection is key to CAR-T cell success. Learn how a serum-free, xeno-free medium boosts transduction efficiency, maintains quality, and streamlines the path to clinical scale-up.

Maximizing MSC Yield And Quality: A Comparative Media Study

Maximize mesenchymal stem cell (MSC) expansion with a simplified culture process. Learn about a high-performance, xeno-free media that eliminates the need for coatings or media exchanges.

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Webinar: Overcoming Regulatory Hurdles in AAV Production

As CGT advances, regulatory expectations continue rising—especially around demonstrating clearance of residual reagents in viral vector production. In this webinar, Miguel Dominguez and Lloyd Achirem from Mirus Bio (part of MilliporeSigma) share how strategic partnerships and a newly developed residual reagent assay simplify submissions and strengthen quality assurance. Learn how their practical innovations support more efficient, compliant, and future-ready AAV manufacturing. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

Bring The Power Of Versatile Incubator Shakers To Your Lab - INFORS HT

Complete Cell Culture Media Solutions For Primary MSCs - FUJIFILM Biosciences

Cell Line Characterization Testing Package - Minaris Advanced Therapies

Unlock The Power Of Precision With Recombinant Cytokines - Lonza

Breaking Productivity Barriers In Upstream Bioprocessing - Repligen

Cell Culture Media For Viral Vector Production - Cytiva

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