Newsletter | February 5, 2025

02.05.25 -- How 'Explainable ML' Can Improve Process Performance

SPONSOR

Chromatography webinar on recombinant protein process development

Join the webinar “Recombinant protein process development and scale-up with Cytiva™ Protein Select™ resin” on 13 February 2025. Cytiva Protein Select resin enables standardized affinity purification for recombinant proteins that lack an affinity binding partner. Process development gets easier, faster, more efficient. Fewer chromatography steps are required, which improves process time and cost.

FOCUS ON FILL-FINISH

Introducing Laminar Airflow Technology In Aseptic Processing

The global market for injectable drugs will reach $69.13 billion by 2028. Examine the vital role of laminar airflow technology in meeting sterile integrity standards and minimizing contamination risks.

Ensuring Homogeneity In Biopharmaceutical Aliquotation

Tired of manual manipulation risks in biopharmaceuticals? Automated homogenization ensures consistent cell counts and concentration levels, improving patient safety and process reproducibility.

Challenges Associated With In-Use Simulated Administration Of Biologics

Explore some of the more challenging aspects surrounding in-use testing for parenteral delivery along with potential strategies to address these issues.

FILL-FINISH SOLUTIONS

Bioprocessing Bag Ports - Nordson MEDICAL

Handle Your Drug Product With The Highest Quality, Safety - FUJIFILM Diosynth Biotechnologies

SPONSOR

Following its popular inaugural 2024 Bio-Expo Live, Bioprocess Online brings you the next opportunity to advance your drug development agenda. Over just a small portion of your week and from the comfort of your computer, discover the latest solutions in upstream and downstream bioprocessing as well as bioprocess quality, data, and analytics. 15-minute presentations from leading suppliers will give you just the right insight to make your next best move in drug development. Register here.

FOCUS ON DOWNSTREAM MANUFACTURING

How 'Explainable ML' Can Improve Process Performance

In a case study, chromatography process data converted into "images" equipped artificial intelligence to help manage dynamic binding capacity degradation.

Enhance Virus Clearance Process Capability With Biodegradable Detergent

Learn more about an effective, biodegradable solution for the viral inactivation process that controls protein impurities and is compatible with downstream unit operations.

Best Practices For Chromatography Column Packing

Proper packing for resin is crucial to prevent issues like cracking or channeling which can lead to process disruptions and product loss.

Multi-Tiered Classification For Downstream Process Intensification

Watch to learn about the various levels of intensification, core technologies used in the industry, and the impact of each level on productivity through a monoclonal antibody (mAb) platform.

Solving Bispecific Antibody Heavy-Light Chain Mispairing

Explore how the bYlok® bispecific pairing technology can be used to solve heavy-light chain mispairing in bispecific antibodies and how it compares with alternative scaffolds.

Achieving Impurity Clearance During mAb Purification With A Single Media

Is the mAb purification process limiting your progress and productivity? Using a ceramic hydroxyapatite could help address an inability to achieve proper clearance of impurities.

Effect Of NK-EVs, Carboplatin On Osimertinib-Resistant Lung Cancer Cells

Delve into a study that examines the possibility of the combination of NK-cell-derived EVs and CBP as a viable immunochemotherapeutic strategy for resistant cancers.

SPONSOR

Webinar: Efficient Downstream Processing of Antibody-Based Therapeutics – A CDMO Perspective

The purification of therapeutic monoclonal antibodies has become increasingly standardized, yet not all platform processes achieve the same level of efficiency. Join us as industry experts discuss downstream process development, trade-offs between speed, cost, purity, and yield, and strategies for handling complex molecules. Click here to learn more.

DOWNSTREAM MANUFACTURING SOLUTIONS

DurA Cycle A50 Chromatography Resin - Ecolab, Purolite Resins

Protein Characterization And Metabolomic Analysis - 908 Devices

EndonucleaseGTP ELISA Kit - Cygnus Technologies Inc.

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