Enhancing Virus Clearance Process Capability Using A Biodegradable Detergent

By Tuhidul Islam, Dr. Nandu Deorkar, and Dr. Jungmin Oh

Does your high concentration mAb needs a new approach to viral clearance? Low pH treatment can lead to instability, and Triton X-100 was placed on the Substances of Very High Concerns list under REACH regulations. Avantor R&D scientists reacted and found an effective, biodegradable solution for the viral inactivation process that controls protein impurities and is compatible with downstream unit operations for greater performance benefits.