Newsletter | July 21, 2025

07.21.25 -- Closed-Loop Manufacturing Is The Cell Therapy Revolution We Need

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FOCUS ON UPSTREAM MANUFACTURING

Closed-Loop Manufacturing Is The Cell Therapy Revolution We Need

In cell therapy manufacturing, automated closed systems with integrated software controls offer numerous benefits over traditional open systems.

Using Algae To Manufacture Oral Biologics With Lumen Bioscience's Craig Behnke, Ph.D.

Lumen Bioscience is putting the farm in biopharma — literally! In this episode of Better Biopharma, Lumen's EVP of production and development, Craig Behnke, Ph.D., explains the company's chlorophyll-powered approach to bioprocessing using photosynthetic cyanobacteria.

The Impact Of Flexible Environmental Controls On Cell Growth, Viability

Achieving high viable cell densities in HEK293 cultures is crucial. This study examines how precise environmental adjustments support robust growth for gene therapy applications.

A Transient Cell Line To Produce rAAV With Low-Level hcDNA Encapsidation

Discover the ability of a novel HEK293 suspension cell line for efficient and scalable rAAV production across various serotypes with low encapsidated host cell DNA levels.

Optimize Your Manufacturing Process Before You Automate

Dive into specific unit operations and case studies that demonstrate how implementing phase appropriate tools can have substantive direct business impacts to cost and development timelines.

The Role Of Cell Culture Media Growth Factors

Growth factors in cell culture media are essential for cell survival and behavior. Uncover their diverse roles and the science behind choosing the right ones.

Modular Facilities, Smaller Footprint With Dynamic Perfusion

Manufacturers are looking to single-use, flexible solutions when building new facilities or modifying operations. Their goal is to increase productivity across modalities, including difficult-to-express molecules.

Achieve Fast And Efficient Isolation Of Exosomes From Stem Cells

Review this demonstration of a bioreactor and bioreactor system combination used to isolate exosomes after culturing human adipose-derived stem cells in suspension on microcarriers.

Why Is Custom Cell Culture Media So Important?

Customizing cell culture media is an important part of the early stages of development considering its composition is crucial for cellular therapeutics' success

Extracellular Vesicle Isolation From Conditioned Media

Explore a scalable, sterile solution for isolating extracellular vesicles (EVs) in exosome therapeutics to enhance yield, purity, and commercial viability through innovative filtration technology.

Transient Expression Technologies For Antibody Production

Review studies that showcase the potential of the CHOgro Expression System in early stage drug development, where high titer antibody production in suspension CHO cells is crucial.

Non-Viral Delivery Of Complex Cargos For Large-Scale T Cell Manufacturing

Explore an improved cartridge for the electroporation of complex cargos into large volumes of T cells. Discover how to achieve reliable, robust, and efficient delivery of complex, clinically relevant cargos.

Stem Cell Cultivation In Single-Use Stirred Tank Bioreactors

Explore a study aimed at achieving clinically relevant cell numbers using the engineering of a GMP-compliant large-scale platform is essential.

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Webinar: Accelerating Tech Transfer with Integrated, Client-Focused Project Management

Join this upcoming Samsung Biologics webinar to learn how strategic project management speeds up drug substance (DS) and drug product (DP) tech transfers. Discover how co-locating DS and DP, early issue resolution, and strong team collaboration can shorten timelines, improve communication, and support faster regulatory approvals—even for complex biopharma projects. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

Optimization Of Glycosylation - Roche CustomBiotech

Vertical-Wheel Bioreactor: PBS-3 - PBS Biotech, Inc.

Use The Right Tools To Improve Cell Lines And Production Yields - ATUM

Pioneers And Visionaries: Cell Line Development And AAV Gene Therapy - Cytiva

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Webinar: Efficient Scale-Up of Monoclonal Antibody Production: From Bench Top to 500L

Join Thermo Fisher Scientific for a live webinar on scaling Herceptin production in CHO-K1 cells from 3L to 500L using HyPerforma™ and DynaDrive™ bioreactors with Gibco™ Efficient-Pro™ media. Discover how consistent productivity and product quality were maintained across scales, supported by a streamlined downstream process. Gain valuable insights into efficient, scalable monoclonal antibody (mAb) production. Click here to learn more.

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