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Expanding The Role Of Chromatography: From Efficient Biomolecule Purification To Targeted Therapeutic Delivery
As biotherapeutics continue to advance, the need for efficient, scalable, and sustainable purification technologies has never been greater. Innovations in chromatography resins are transforming downstream workflows by enabling high-yield, high-purity recovery of diverse biomolecules—including monoclonal and bispecific antibodies, recombinant proteins, mRNA, and viral vectors. These advanced resins also streamline impurity clearance and reduce the number of process steps, improving overall efficiency.
Beyond purification, chromatography resins are now being leveraged as active components in therapeutic delivery, offering site-specific targeting and controlled release of drugs and radionuclides. Ion exchange resins have demonstrated clinical utility in applications such as selective internal radiation therapy (SIRT) and transarterial chemoembolization (TACE) for cancer treatment, as well as in gene therapy. Together, these advancements in resin technology support both enhanced manufacturing efficiency and expanded therapeutic potential, aligning with industry goals for innovation, sustainability, and improved patient outcomes.
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New Mixed-Mode Weak AEX-HIC Resin For Biomolecule Purification
Unlike traditional ion exchangers, Nuvia™ wPrime 2A Mixed-Mode Media offers tunable charge properties and enhanced selectivity, enabling higher yields, improved impurity clearance, and simplified process optimization across diverse biomolecules—from monoclonal and bispecific antibodies to recombinant proteins and AAV vectors. Learn how this next-generation mixed-mode resin expands the design space to achieve more with less—saving time, resources, and cost while maintaining product quality.
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Enhancing Process Development With Viral Clearance
Viral clearance is a critical component of biopharmaceutical safety, and early assessment during downstream process development helps prevent costly manufacturing changes. Viral clearance studies aim to identify and assess manufacturing steps that effectively remove or inactivate viruses, and to quantify the overall virus reduction achieved. These case studies highlight viral clearance performance using mixed-mode chromatography resins.
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Advancing mRNA Vaccine Development With Mixed-Mode Media
Efficient purification technologies are playing a pivotal role in vaccine manufacturing and gene therapy by enabling the isolation of viruses, viral particles, and mRNA for therapeutic applications. As mRNA vaccines gain prominence, their production involves high-yield, cell-free transcription processes that generate complex impurities such as double-stranded RNA (dsRNA), DNA templates, and free nucleotides. Mixed-mode chromatography offers a powerful solution for selectively removing these impurities. Learn how these chromatography resins play a vital role in purification.
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Advancing Targeted Therapies With Chromatography Resins
Chromatography resins are no longer just tools for purification—they are now being used as active components in cutting-edge therapies for cancer, inflammatory disorders, and gene delivery. Ion exchange resins have demonstrated strong potential in microsphere-based treatments, offering precise drug release, targeted delivery, and stability for radionuclide labeling. Learn how these resins are paving the way for innovative, site-specific therapeutic strategies.
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Transforming Biomanufacturing With Ready-to-Use Columns
Traditional chromatography workflows can face challenges such as high production costs, scalability issues, and variability in column packing that can affect product quality and regulatory compliance. Prepacked chromatography columns, such as Foresight Pro Columns, offer a GMP ready solution that improves consistency, reduces labor and operational costs, streamlines scale-up, and enhances flexibility in biomanufacturing. Packed with CHT™ Ceramic Hydroxyapatite Media from 5–45 cm ID, Foresight Pro Columns are backed by Bio-Rad’s proven CHT packing expertise, exceptional service, and reliable supply to ensure your purification is successful.
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Simplify Resin Selection And Screening
Screening chromatography resins can accelerate method development and optimize downstream purification workflows. Bio-Rad’s interactive Resin Selector Tool empowers you to explore an extensive chromatography resin portfolio through guided questions. Find the right solutions and request resin samples directly.
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