Exploring The Use Of Multimodal Chromatography For The Purification Of mRNA Vaccines

Efficient mRNA purification is critical for therapeutic development, yet traditional workflows often struggle with removing impurities like dsRNA, DNA templates, and free nucleotides. This webinar introduces a mix-mode chromatography approach that simplifies purification into a single step—achieving over 80% mRNA recovery and more than 88% purity. By optimizing binding and elution conditions, this method eliminates over 65% of dsRNA, significantly improving downstream quality. The streamlined process not only enhances yield and purity but also reduces manufacturing complexity and supports scalability for clinical and commercial production. Whether you're refining your mRNA workflow or scaling up for therapeutic applications, gain actionable insights to help you get there faster.

Explore how this technique can transform your mRNA purification strategy.