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Adapting Downstream Purification to the Next Generation of Biologics
As biologic modalities become more complex, downstream purification strategies must adapt to increasingly diverse molecules, impurity profiles, and manufacturing requirements. From non-platform process development and scalable ADC purification to mixed-mode chromatography for multispecific antibodies and streamlined mAb workflows, purification scientists and engineers need greater flexibility and selectivity across the process. Explore technical strategies that can strengthen impurity clearance, improve product recovery, reduce process complexity, and support reliable transfer to process-scale manufacturing.
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FROM NON-PLATFORM DEVELOPMENT TO MANUFACTURING WITH PREPACKED PROCESS-SCALE COLUMNS
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Challenging biologics may require purification strategies tailored to molecule-specific behavior. A webcast presented by FUJIFILM Biotechnologies demonstrates development and transfer of a bespoke downstream process to large-scale cGMP manufacture using Foresight™ Pro Columns prepacked with CHT™ Ceramic Hydroxyapatite media. Foresight Pro Columns are now also available prepacked with Nuvia™ ion exchange and mixed-mode resins, providing greater flexibility through additional chromatography chemistries within the same GMP ready platform.
Webcast | Nuvia Prepacked Columns | Scale-Up Guide
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SCALABLE PURIFICATION STRATEGIES FOR ANTIBODY-DRUG CONJUGATES
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Antibody-drug conjugates can introduce distinct downstream processing challenges because of their molecular complexity. Explore scalable purification strategies that can help scientists and engineers evaluate separation options, manage process complexity, and develop workflows that are better suited for progression from process development to manufacturing.
Webcast | Case Study | Purification Guide
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ENHANCING BISPECIFIC AND TRISPECIFIC ANTIBODY PURIFICATION USING MIXED-MODE CHROMATOGRAPHY
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Bispecific and trispecific antibodies can generate closely related variants and complex impurity profiles that are difficult to resolve using conventional chromatography. Learn how mixed-mode chromatography, including CHT Ceramic Hydroxyapatite, can provide complementary selectivity for removing aggregates, host cell DNA, and other impurities. The case studies can help process scientists and engineers assess where mixed-mode separations may strengthen challenging purification workflows.
Webcast | Purification Strategy | Application Guide
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A TWO-STEP APPROACH USING A MIXED-MODE RESIN FOR MAB PURIFICATION
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Traditional mAb platforms commonly use Protein A capture followed by two polishing steps. This webinar presented by Minapharm Pharmaceuticals examines how an optimized Nuvia™ aPrime 4A mixed-mode step can support a two-step strategy after Protein A capture, reducing process time, buffer use, and media requirements while increasing product yield. The approach gives purification teams a practical framework for simplifying downstream workflows while maintaining focus on product purity and viral clearance.
Webcast | Purification Strategy | Viral Clearance Guide
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OPTIMIZING ANTIBODY POLISHING WITH MIXED-MODE CHROMATOGRAPHY
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Efficient mAb polishing requires balancing impurity clearance with product recovery. See how a DoE-guided approach optimized Nuvia™ wPrime 2A Media for aggregate removal in flow-through mode, reducing high molecular weight species from 7.3% to 0.7% while achieving 85% mAb monomer recovery. The experimental approach can help scientists and engineers define operating conditions and evaluate polishing performance using measurable process outcomes.
Webcast | Expert Advice | Application Guide
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FIND THE RIGHT RESIN FOR YOUR PROCESS
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As purification challenges evolve with next-generation biologics, selecting the right chromatography media becomes increasingly important. Explore resins with different chemistries and selectivities for downstream process development. Use Bio-Rad's Resin Guide to identify candidates for screening and determine the best fit for your purification workflow.
Webcast | Sample Request | Resin Guide
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RESOURCES TO ACCELERATE YOUR BIOTHERAPEUTIC DEVELOPMENT
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Explore our interactive resin selection tools, request resin samples, and connect with purification specialists to address complex downstream purification challenges. Access technical expertise and application support for method development, process optimization, scale-up, and manufacturing.
Explore Resin Selection Tools
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