Newsletter | October 23, 2026

10.23.26 -- AstraZeneca's Focus On Predictive Control, Semi-Autonomous Processing

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Accelerating Bulk Harvest Testing

The combination of the Blazar® panel with rapid methods for mycoplasma, sterility and RVLP detection offers the potential to reduce the overall turnaround time for CHO bulk harvest testing from 35 days to 14 days. Read the Application Note here.

FOCUS ON PROCESS ENGINEERING

How Isogenic Organ-Chips Are Transforming The Future Of Research

Modeling the human brain requires more than simplified systems. New approaches that incorporate diverse cell types are improving how researchers study neurovascular function with greater precision.

Advancing In-Line PAT Solutions For Real-Time Batch Analysis

Shift from reactive sampling to continuous, data-driven control. Learn how in-line metabolic monitoring improves yield and batch consistency through real-time glucose and lactate insights.

Cell Culture Media Mixing In A Benchtop Single-Use Mixer

Explore how efficient powder-liquid mixing and sterile filtration preserve media integrity and support reproducibility in biopharmaceutical workflows, with promising scalability for larger-volume applications.

Scalable Electroporation Optimizes Transposon Delivery

See how electroporation can be used to efficiently engineer T cells for CAR T cell manufacturing workflows with piggyBac™ transposons while maintaining high viability and cell yield.

Looking Beyond Solubility And Process Performance

Solvent selection for spray-dried dispersions significantly impacts performance, scalability, and supply chains. Early, structured solvent choice is vital for successful manufacturing.

How To Choose The Right MES Or Manufacturing Operations Platform

Selecting an MES platform has lasting consequences for compliance and operational insight. Delve into key considerations that help manufacturers choose systems built for long-term performance.

Rethinking Design, Cost, And Scalability In Biomanufacturing

Life science teams increasingly need tools that scale, simplify workflows, and reduce operational costs. Examine how emerging instrumentation focuses on usability, performance, and manufacturability.

The Art Of Protein Expression: A Guide To Understanding Difficult Proteins

Protein expression failures often result from misfolding, PTMs, assembly issues, insolubility, and toxicity. Understanding their interplay can improve yields.

Autonomous Impinging Jet Mixing For LNP Process Development

Discover how impinging jet mixing combined with automation and data-driven optimization offers a more systematic path to identifying process parameters for scalable, reproducible LNP manufacturing.

Early Developability Assessment For Antibody Based Therapeutics

Find out how an integrated developability and immunosafety toolbox can help de-risk multi-specific antibody development, improve candidate selection, and accelerate complex biologics toward the clinic.

Digital Innovation And Sustainability Are Redefining Biomanufacturing

Next Generation Manufacturing (NGM) integrates advanced process design, digital innovation, and strategic facility planning to facilitate agile, efficient, and sustainable biopharmaceutical production.

Model-Driven Genetic Design And Bioprocess Optimization Across Modalities

Traditional biomanufacturing relies too heavily on trial and error. By integrating AI and mechanistic models into early design, developers can overcome productivity limits and accelerate timelines.

Reaching BLA Success: Fast-Track Approach To Process Characterization

Gain insight into how knowledge of microbial processes and process characterization understanding can be used to design targeted BLA programs while managing risks.

A Smart Path For Novel Biologics

Read more about a solution for streamlining workflow in novel biologics while collecting quality data, by combining single-use microbioreactors with advanced automation and analytical platforms.

PROCESS ENGINEERING SOLUTIONS

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Chemically Defined Media System For Scalable Exosome Manufacturing - RoosterBio

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Reduce Scientific Workflow Delays Without Adding Manual Handoffs - Revvity Signals Software, Inc.

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Implementing Scalable Training Excellence In CGT Manufacturing - Miltenyi Biotec

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Webinar: Accelerating CHO Manufacturing: From 14-Day Fed-Batch to 10-Day Intensified Fed-batch

What if you could shorten a 14-day fed-batch process to just 10 days without sacrificing product quality? This Thermo Fisher Scientific webinar explores how N-1 perfusion intensified CHO-K1 Herceptin production using standard equipment and the same medium, while scaling from Ambr 250 to 50 L. Discover practical strategies to increase throughput, flexibility, and manufacturing capacity without significant process changes. Click here to learn more.

FOCUS ON SUPPLY CHAIN

AstraZeneca's Focus On Predictive Control, Semi-Autonomous Processing

This article captures key takeaways from a BioProcess International keynote by Preeya Boppana, director of MSAT process analytics and laboratories at AstraZeneca, titled “Transforming Biologics Manufacturing: Leveraging Predictive Analytics and Advanced Process Control for Next-Generation Operations.”

Empowering Biopharma With Single-Use Cryopreservation Solutions

Take a look at four common applications of cryopreservation and the science behind selecting the appropriate materials to build single-use solutions that enable cryogenic storage for applications.

SUPPLY CHAIN SOLUTIONS

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Safeguard Valuable Biopharmaceutical Materials In Cold Chain - W.L. Gore & Associates

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