Despite the availability of production methods for adeno-associated virus (AAV) vectors, they are still difficult to manufacture at large scale. Explore optimization of upstream AAV process development in proprietary scale-down cloud-connected bioreactors, including increasing the fraction of full AAV capsids.
Explore a successful collaboration between Cytovance Biologics and Culture Biosciences where a fermentation process was transferred, downscaled, modified, and improved via Design of Experiments (DOE), then verified and transferred back to Cytovance Biologics in just a few experiments. This resulted in a two-fold increase in titer over six experimental runs.
Running benchtop bioreactors requires significant resources, infrastructure, staffing, and time. This article showcases a fleet of 250mL bioreactor systems designed to run off site in the cloud and deliver the reproducible outcomes of its use in both mammalian cell culture and fermentation applications.
How can a cloud-native platform help you determine accurate performance metrics from a cell culture experiment? This article showcases a platform that allows scientists to calculate growth and consumption rates, compare variability in cell lines, and achieve faster, more accurate knowledge extraction from cell culture experiments.
The constraints of a strain screening program, combined with the expected effect size, desired statistical power, and observed bioprocess variation, often require a sample size exceeding available bioreactor capacity. Discover how power analysis can help determine the correct sample size for a statistically powered clone screening experiment.
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