Supplemental Bioreactor Capacity Accelerates Bioprocess Development

By Masaki Yamada, Kris Tyner, Firehiwot Tachea, Saede Moseley, Jason Wong, Chelsea Edgar, Katie Madler, Matt Ball

When up against aggressive development timelines and technical milestones, access to additional methods of generating bioprocessing data can significantly accelerate the speed of drug development. Here, this paper describes a successful collaboration between Cytovance Biologics and Culture Biosciences where a fermentation process was transferred, downscaled, modified, and improved via a Design of Experiment (DOE), then verified and transferred back to the client in just a few experiments. This resulted in a two-fold increase in titer over the course of six experimental runs, demonstrating that rapid progress can be made by synergizing internal capacity with guaranteed capacity, resources, and expertise in Culture’s Cloud Bioreactor Lab.