Discover In Vitro Glycoengineering

Achieving lot-to-lot consistency is essential for biopharmaceutical manufacturing and a core principle of Quality by Design (QbD). However, the inherent variability of fermentation can make controlling glycosylation patterns a persistent challenge, leading to project delays. In vitro glycoengineering (IVGE) offers a solution by moving glycosylation management out of the bioreactor and into the downstream process.

This targeted approach grants greater control over this CQA, simplifying technology transfers and reducing the risk of variability between batches. By using a toolbox of highly active enzymes, you can systematically and predictably optimize the glycan structure after fermentation, ensuring consistent results from development to large-scale manufacturing.

Discover how IVGE can enhance your process control and consistency.