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  • How Can You Mitigate The Risks Of Single-Use Bags?
    How Can You Mitigate The Risks Of Single-Use Bags?

    The loss of product as a result of bag failure isn’t just an annoyance; it’s an expense, and a costly one at that. However, Chuck Hart, director of manufacturing at Prolong Pharmaceuticals, says with proper fitting and handling, these concerns can be mitigated.

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  • Determination Of k<sub>L</sub>a Values Of Single-Use Bioreactors
    Determination Of kLa Values Of Single-Use Bioreactors

    Single-use bioreactors are increasingly used in research, process development, and production. Like conventional reusable systems they have to allow the setup of optimal growth conditions. A sufficient supply of oxygen is crucial for aerobic bioprocesses, and the velocity of oxygen entry into the culture medium is often described by the volumetric mass transfer coefficient (kLa). Because single-use bioreactors offered by different manufacturers vary in parameters critical for oxygen transfer—like mixing, power input, and gassing strategies—they are often not directly comparable to each other and to conventional glass and stainless steel vessels. Even kLa values experimentally determined by the manufacturer or users are not necessarily comparable, because the results might differ dependent on the method used.

  • Comparing Glass And Single-Use Bioreactors For Growth And Production Of Secreted Proteins
    Comparing Glass And Single-Use Bioreactors For Growth And Production Of Secreted Proteins

    The packed-bed basket technology, developed by New Brunswick Scientific (acquired by Eppendorf Inc. in 2007), provides a shear free environment for production of animal cells. At present, little information is available on the utility of the New Brunswick CelliGen® BLU singleuse bioreactor system for the production of secreted proteins, especially in perfusion mode of operation.

  • Comparing Single-Use Bioreactors To Reusable Bioreactors For Production Of Recombinant Proteins
    Comparing Single-Use Bioreactors To Reusable Bioreactors For Production Of Recombinant Proteins

    The objective of this study was to compare Eppendorf BioBLU single-use packed-bed bioreactor vessel and the traditional glass vessel counterpart used in New Brunswick™ CelliGen® 310. Alkaline phosphatase (ALKP)- secreting Chinese Hamster ovary (CHO) cells were used to measure ALKP production in each bioreactor.

  • Effect Of Sterilization On Mechanical Properties Of Silicone Rubbers

    Silicone rubber is widely used in the pharmaceutical industry where sterilizability is an essential requirement for all fluid transfer equipment. Pharmaceutical products must be sterilized frequently and repeatedly by high level energy and/or chemical vapor in order to eliminate bacterial surface contamination.

  • Streamlining The Biological Factory: Making A Better CHO Cell For Biopharma Production

    SAFC’s CHOZN® Platform has been developed as a ‘plug and play’ manufacturing system for the creation of biopharmaceutical producing cell lines.

  • Save Up To 8 Hours In Cell Line Development With ZFN Technology

    Zinc finger nucleases (ZFNs) have proven to be a powerful tool for modifying genes. In comparison to traditional techniques, such as adding chemical or radiation based mutagens that cause various random mutations, ZFNs can create very accurate, targeted changes to the genome in a much more rapid fashion.

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Benchtop SIP Bioreactor Systems: CelliGen&reg; 510 Benchtop SIP Bioreactor Systems: CelliGen® 510

The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.

Photometer With UV And Vis Measurements: BioSpectrometer&reg; Photometer With UV And Vis Measurements: BioSpectrometer®

With the Eppendorf BioSpectrometer basic, measurements can be executed in the UV and Vis range from 200 nm to 830 nm. The freely selectable wavelengths offer you maximum flexibility during these procedures.

Single-Use Bioreactor System: CelliGen&reg; BLU Single-Use Bioreactor System: CelliGen® BLU

New Brunswick’s CelliGen® BLU combines the benefits of single-use technology with the performance and scalability of a stirred-tank design.

Cation Exchange & Anion Exchange Membranes: Natrix® HD Membrane Technology

Natrix HD Membranes offer a breakthrough in membrane architecture that will forever change downstream purification. Available in two chemistries: Q (strong anion exchange) and Sb (strong cation exchange and hydrophobic group).

sCMOS Cameras for OEM sCMOS Cameras for OEM

These new OEM cameras from Hamamatsu feature an advanced scientific CMOS (sCMOS) image sensor capable of high resolution, fast frame rates, and low noise simultaneously. With their small size, board-level design, and simple, low-cost integration, these OEM cameras are ideal for imaging in life science, failure analysis, and semiconductor inspection.

HyPerforma™ Single-Use Fermentor (S.U.F.) HyPerforma™ Single-Use Fermentor (S.U.F.)

The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work is streamlined – offering you cost savings and efficiency. 

Flexsafe Single-Use Bags Flexsafe Single-Use Bags

Standard Flexsafe 2D validation bags made of the new polyethylene S80 film are designed for small scale investigations and for the validation of the Flexsafe bag family. They are available in 150 mL and 500 mL volumes to support end users’ process development and validation testing. Flexsafe bags have been designed by combining material science and a Quality by Design approach to provide outstanding cell growth, robustness and assurance of supply for all process steps of biomanufacture.

Pharmaceutical Containment of Powders Pharmaceutical Containment of Powders

Storage of pharmaceutical compounds is a function of the storage process and not a specific containment driven requirement per se. This is the case whether you are processing in a contained fashion or performing non-contained processing into open kegs with simple drum liners.

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