Single Use Featured Articles

11. Poster: Utility Of Automated Drug Transport Assays In 96-Well Format, Using Permeable Support Systems 3/1/2011
    Cell-based drug transport assays, such as Caco-2 and MDCK, are an essential component of ADME/Tox testing for lead compounds. The permeability and transport data they provide can determine whether or not a compound is carried forward in the drug discovery process. By Brad Larson, Peter Banks, Hilary Sherman, Mark Rothenberg
12. Poster: A Fluorescence Microplate-Based Assay Workflow For High-Throughput Screening Of Compounds Modulating Autophagy In Living Cells 3/1/2011
    Autophagy is a normal degradative pathway that involves the sequestration of entire organelles, protein complexes, and misfolded proteins in a membrane vacuole called the autophagosome. By Paul Held, Dee Shen, Peter Banks, and Wayne Patton
13. Article: Single-Use Connections Enable Advancements In Aseptic Processing 2/2/2011
    Today’s market demand for new drugs — combined with the difficult economic environment — is challenging bioprocessors to review their manufacturing systems and seek ways to make them more flexible, reliable, and cost effective. By John Boehm
14. Automated, Single-Use Purification Platforms In Biopharmaceutical Production 12/3/2010
    The use of disposable bioreactors and single-use purification platforms for Normal Flow Filtration (NFF), Tangetial Flow Filtration(TFF) and Preparative Chromatography have received significant attention in years. Up to very recently, the use of single-use purification platforms was limited almost exclusively to manually operated systems. The transitioning from manual to automated single-use purification systems has been limited primarily by the availability of appropriate sensors and detectors and other in-line system components. By Karl G. Schick, Ph.D., VP of R&D, SciLog Inc.
15. Poster: Stabilization Of Cell-Free RNA In Plasma For Noninvasive Diagnosis And Prognosis 8/18/2010
    The discovery of the presence of cell-free nucleic acids in blood (1) and subsequent demonstrations that cell-free nucleic acids were elevated in certain disease conditions (2) suggested the usefulness of cell-free nucleic acids in non-invasive diagnosis and prognosis. The clinical utility of cell-free mRNA in blood as diagnostic and prognostic markers was first demonstrated in cancer patients (3). The presence of fetal cell-free mRNA in maternal blood was initially reported in 2000 by Poon et al.
16. White Paper: Automated, Single-Use Purification Platforms In Biopharmaceutical Production 7/2/2009

    The use of disposable bioreactors and single-use purification platforms for Normal Flow Filtration (NFF), Tangetial Flow Filtration(TFF) and Preparative Chromatography have received significant attention in years. Up to very recently, the use of single-use purification platforms was limited almost exclusively to manually operated systems. By Karl G. Schick, Ph.D., VP of R&D, SciLog Inc.

17. Long-Term Stability Study And Topology Analysis Of Plasmid DNA By Capillary Gel Electrophoresis 3/27/2009
    The topology of plasmid DNA can be monitored with capillary gel electrophoresis (CGE). An improved CGE technology was developed at PlasmidFactory to routinely determine the content of different plasmid forms that appear during cultivation and purification in DNA production runs. By M. Schleef, R. Baier, W. Walther, M.L. Michel, and M. Schmeer
18. Disposable Membrane Chromatography 2/17/2009
    Disposable devices for unit operations in bioprocessing have been commonplace for some time. Additionally, support systems for each unit operation have also become disposable. They include aseptic bags for buffer and product storage and filters to ensure sterility. The most common disposable devices for unit operations are filters used to clarify harvests and protect columns, virus retentive filters, sterilizing-grade filters for fill and finish, and in some cases crossflow filters for product concentration and buffer exchange. By Jeff Mora, Andrew Sinclair, Noushin Delmdahl, and Uwe Gottschalk
19. Safety, Containment, Filtration Efficiency And Energy Conservation Make The Paramount® Ductless Enclosure A Viable Alternative To A Ducted Fume Hood 1/30/2009
    Safety is the primary purpose of any filtered enclosure or ventilated fume hood. In most situations, fume hoods remain the equipment of choice for ventilating hazardous airborne chemicals from the laboratory. However, there are applications where a ductless enclosure or ductless hood provides convenience and flexibility beyond what a traditional fume hood offers. By Gary Roepke, Senior Project Engineer, Labconco Corporation
20. Silicone Molded Tubing Assemblies: A Solution For Reduced Contamination Risk And Greater Efficiency 1/13/2009
    The adoption of single-use systems is one of today’s most noteworthy trends in biopharmaceutical processing. The next-generation solution, molded tubing assemblies made of silicone, can help reduce the risk of contamination in biopharmaceutical and pharmaceutical processing. By Roger Hendrick, Audrey Wipret