product datasheets, catalogs, app notes
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1X PBS (Phosphate Buffered Saline) Buffer Mixing Optimization
4/23/2021
This study develops optimal process conditions for mixing and filtering of 1X PBS buffer using the 50 L, 200 L, and 1000 L Mobius® Single-Use Mixing Solution, Durapore® and Millipore Express® filters.
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Optimizing Downstream Processing For An Inactivated Rabies Vaccine
3/17/2021
This app note describes improvements made to the downstream portion of the process, specifically, use of single-use technologies and novel techniques for clarification and ultrafiltration/diafiltration.
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Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio
3/12/2021
Did you know about the alternative rapid method for in vivo MAP/HAP/RAP testing? Download our tech note Blazar® Platform: Rodent Virus Panel From The BioReliance® Portfolio to learn more about our novel degenerate PCR assay designed for the detection of a broad range of adventitious agents.
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Optimization Strategy And Process Economics Of DNA Digestion In Viral Vector Production For Gene Therapy
12/16/2020
Benzonase® endonuclease is a high-quality product delivering immense value to viral vector processes. The enzyme activity is strongly influenced by the matrix, and optimization of its use should be a mandatory step in process development. In this application note, we highlight an optimization strategy and process economics of DNA digestion in viral vector purification.
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Tangential Flow Filtration (UF/DF) Of Plasmid DNA
12/16/2020
Learn how optimization of hydraulic parameters can help you achieve the desired plasmid purity, formulation, and concentration specifications.
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Sterilizing Grade Filtration Unit Operations For Plasmid DNA Processes
11/19/2020
The large size of pDNA can present a challenge for sterile filtration unit operations within your gene therapy manufacturing since the product can be retained by the filters, leading to both yield loss and low filtration capacity. Optimization of a sterilized grade filtration unit can help increase yield and filtration capacity. Read on to learn more!
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Chromatographic Purification Of Plasmid DNA
11/19/2020
Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).
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Integritest® 5: Integrity Assurance With Ease And Confidence Datasheet
11/12/2020
Accurately and reliably verify the integrity of your filters and processing equipment with the portable, easy to implement, and automated Integritest® 5. The Integritest® 5 delivers a simple and intuitive user experience, while providing optional depth of flexibility to fit your process.
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Bubble Point Testing With Integritest® 5
11/12/2020
During a bubble point test, pressure decay measurements are taken at increasing applied transmembrane pressures to map the filter’s integrity profile. The Integritest® line of automated integrity testing instruments identifies optimum pressures at which to take measurements based on test parameters and ongoing readings, which reduces the number of measurements needed to reliably map the filters’ profile and return an accurate result.
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Automation For Integritest® 5
11/12/2020
The IT5's automation features allow for real-time communication and control of the instrument through secure OPC UA (Open Platform Communications united Architecture) communication, ensuring reliability and security for filter integrity testing.