Application Note

Pellicon® Capsules For Ultrafiltration/Diafiltration In The Antibody Drug Conjugate Manufacturing Process

ADC

Tangential flow filtration (TFF) is essential in the manufacturing of antibody drug conjugates (ADCs). Ultrafiltration (UF) is used to concentrate the protein product and diafiltration (DF) to exchange buffer and/or remove process-related impurities from the ADC solution, including residual linker, organic solvent, and/or free drug. Clearance of organic solvent is required when processing the ADC solution directly after conjugation, for which the TFF filter must be solvent-compatible. ADC manufacturing also requires a containment strategy during post-conjugation TFF steps to protect operators from health risks associated with exposure to the highly potent ADC molecule and free drug, all while preventing contamination of the product and the environment. As a result, single-use TFF devices are a natural choice for UF/DF operations in ADC manufacturing.

In this application note we review a single-use TFF device that increases operator safety, and also saves time for improved batch turnaround and flexibility in the ADC manufacturing plant.

VIEW THE APPLICATION NOTE!
Signing up provides unlimited access to:
Signing up provides unlimited access to:
  • Trend and Leadership Articles
  • Case Studies
  • Extensive Product Database
  • Premium Content
HELLO. PLEASE LOG IN. X

Not yet a member of BioProcess Online? Register today.

ACCOUNT SIGN UP X
Please fill in your account details
Login Information
ACCOUNT SIGN UP

Subscriptions

Sign up for the newsletter that brings you the industry's latest news, technologies, trends and products.

You might also want to: