Jon O'Connell Articles

1. Inside March Biosciences' CD5-Targeting CAR-T Approach 5/4/2026

   Fratricide is one of the key reasons T-cell therapies targeting T-cell malignancies have faltered. March's approach aims to solve that with its MB-105 candidate.

2. The Stepwise Path Lilly Mapped From Paper To Digital Logbooks 4/30/2026

   Eli Lilly and Company started at the front lines, on the shop floor gathering operator input, when switching from paper to digital logbooks.

3. Validating Candel's BLA-Ready Analytics Profile 4/22/2026

   The adenovirus/prodrug company discusses in-house assay development and the validation work to confirm CQAs like potency and cell line integrity.

4. Lilly's Unified Mindset For A Global Parenteral and Device Manufacturing Network 4/17/2026

   Eli Lilly and Company's one-team mindset aims to templatize facility design while remaining nimble enough to react to new manufacturing breakthroughs.

5. Dynamic Flux Analysis Offers Faster Metabolic Modeling Than DOE 2/27/2026

   By continuously analyzing spent media, researchers can estimate reaction rates at regular time points, providing a granular view of cell metabolism.

6. A Novel In Vitro Glycosylation Approach For Difficult PTMs 2/19/2026

   Post-translational modifications of membrane proteins have been historically challenging. Research shows how an in vitro approach brings stability and predictability.

7. Using Carbon Nanotubes To Pinpoint Optimal Harvest Time in Bioprocessing 2/18/2026

   Cell-free expression systems confound the moment of peak expression. These nanosensors signal through crude lysate for process optimization and endpoint monitoring.

8. A Peek Into Novo Nordisk's Sustainable Facility Construction Mindset 2/18/2026

   Fill/finish operations are famously resource-heavy. Nonetheless, Novo set out to achieve ambitious environmental goals with its $4.1 billion project in North Carolina.

9. This Industrial Fungus Has Protein Expression Promise For Pharma 2/12/2026

   Trichoderma reesei is well characterized for industrial uses. A Finnish research group is exploring it for pharmaceutical protein expression.

10. New ISPE Framework Targets Uncertainty In Pharma's AI Deployment 1/29/2026

    International Society for Pharmaceutical Engineering members developed the guide to offer a risk-based framework for evaluating, implementing, and maintaining AI systems.