Expert Insights On Downstream Bioprocessing

1. Common Manufacturing Challenges For LBP Formulations 4/23/2025

   As more companies explore live biotherapeutic products, ensuring stability is likely to be front and center with unique challenges for oral and topical applications.

2. Why You Need A Raw Material Control Strategy 4/17/2025

   You should start with the end goal in mind, but the first draft is almost never the last. These living documents should evolve as your team gains process knowledge.

3. A Closer Look At Buffer Recycling For More Sustainable Bioprocessing 4/8/2025

   Recognizing the unexplored potential to save resources, one researcher realized consumption reduction of up to 50% during a key phase of downstream processing.

4. Amgen's Deep Learning Approach To Vial Inspection 3/31/2025

   The company is testing how artificial intelligence can help bring down the number of false rejections caused by factors like glare on the glass or bubbles in the vial.

5. Using Digital Shadows To Reinforce Downstream Modeling 3/26/2025

   This model class transfers real-time information in one direction, and it can help bridge the gap between digital model and fully functioning digital twin.

6. 3 Strategies For mAb Manufacturing: How Do You Choose? 3/19/2025

   As cost and supply come under more scrutiny, there are primarily three scaling strategies for mAb manufacturing that can be leveraged, each with its own set of pros and cons.

7. Do Patient Needs Define Biologic Product Specifications? 3/14/2025

   Enhanced product understanding acknowledges the technology advancements of the last 25 years and substantially more complex drug modalities.

8. Intensifying Downstream Processing With Magnetic Separation 3/10/2025

   A technique used widely in other industries like steel production and wastewater treatment has emerged as rising star within bioprocessing over the last 10 to 15 years.

9. How To Optimize Downstream Separation With Tagless Proteins 2/26/2025

   The intein-based magnetic bead system enables effective affinity capture, tag removal, and buffer exchange, supporting direct analytical applications.

10. ADC Manufacturing's Biggest CMC Challenges And Ways To Approach Them 2/19/2025

    Manufacturing ADCs is inherently more complex than other biologic drug products. Let's explore some of the key issues, including aggregation, solubility, and thermal instability.