Expert Insights On Downstream Bioprocessing

1. TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration 12/8/2025

   When configured correctly, TFF provides the gentle processing environment and oxygen protection required for strict anaerobes.

2. Strained Manufacturing, Complexity Stymie In Vivo Progress 12/4/2025

    Explicitly mapping delivery challenges to the associated GMP process steps converts biological risk into operational risk.

3. Dual Membrane Preconditioning Can Improve Concentration, Cut HCPs 10/27/2025

   Research from Penn State, the FDA, and Takeda shows how combination filtration and purification steps improve output and reduce impurities.

4. Pfizer's Accord For A Healthier World Program Challenges Stability Study Norms 10/22/2025

   The company developed a novel approach to address the historic lack of stability testing for underserved parts of the world, near the equator.

5. Survey: 30% Of Biopharmas Cite Cost, Productivity As Top Priorities 10/6/2025

   Both focus areas aim at the same outcome, stronger economics and sustainable competitiveness, according to BioPlan Associates' 22nd Annual Biomanufacturing Report.

6. Unlocking Method Insights For Novel Engineered AAV Capsids 9/18/2025

   Microfluidic platforms, such as labchip, are widely used for assessing wild type capsids. Now, engineered capsids are challenging these established workflows.

7. How AbbVie's Digital Transformation Brought Platform Knowledge Closer 9/9/2025

   A custom-built digital ecosystem reduced the time spent on documentation in AbbVie's bioprocess development labs by about 70% for some experiment types.

8. A Case Study In Continuous Process Verification 9/8/2025

   CPV can strengthen the bridge between compliance and continuous improvement. In this scenario, a hypothetical lab sets out to improve process yields and efficiency.

9. Optimizing Lentiviral Vectors For Allogeneic CAR-T Manufacturing 9/5/2025

   A group of graduate researchers explored VSV-G affinity chromatography as an alternative to the standard anion exchange chromatography or AEX.

10. Lilly's Exploring A Universal AAV Purification Method 9/2/2025

    Serotype-specific resins don't scale gracefully. One team at Eli Lilly and Company is exploring an alternative that skips affinity resins altogether.