Downstream Processing White Papers and Case Studies
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Biomanufacturing Supply Chains
12/22/2011
This white paper examines the major issues with biopharmaceutical supply chains and how to balance inventory and risk optimally in the network.
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Materials Of Construction For Biopharmaceutical Water Systems
1/15/2013
Stainless steels are uniquely qualified for bioprocessing applications not only because of their long service life, availability, and fabricability, but also because they are non-corroding, non-contaminant, can be polished to very smooth finishes, are strong and rigid, can withstand heat and chemical sterilization treatments, and are easily welded. By Michelle M. Gonzalez
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An Automated Profiling Application For G9a Histone Methyltransferase And Bromodomain Proteins
Due to several findings, G9a and BET bromodomain proteins have become the target for numberous drug discovery projects. In this study, we describe a novel, cell-based assay platform that uses the robust, yet simple Enzyme Fragment Complementation (EFC) Technology.
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Comparing Single-Use Bioreactors To Reusable Bioreactors For Production Of Recombinant Proteins
4/15/2016
The objective of this study was to compare Eppendorf BioBLU single-use packed-bed bioreactor vessel and the traditional glass vessel counterpart used in New Brunswick™ CelliGen® 310. Alkaline phosphatase (ALKP)- secreting Chinese Hamster ovary (CHO) cells were used to measure ALKP production in each bioreactor.
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Compound Profiling And Toxicity
Utilizing a systems approach to drug discovery has generated a multitude of high affinity compounds for various classes of molecular targets with different degrees of disease state validation.
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Weathering The Storm Of Regulatory Compliance In Aseptic Manufacturing
7/30/2012
When the U.S. Food and Drug Administration (FDA) conducts an unscheduled inspection of your aseptic manufacturing process, it can hit with the fury of a New England nor’easter. But just as careful planning and forecasting help us safely ride out the storm, a best-practice control and monitoring system minimizes the danger of FDA noncompliance. By Alex Mello, Microtest
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Avoiding Drug Shortages With Microbial Detection
3/6/2013
Over the past year, critical drug shortages used to treat a host of life-threatening illnesses have been making headlines. Microbial contamination has been cited as a major contributor to the shortage, yet the prevailing practices to ensure the safety of drugs have been slow to change. In most cases, quality assurance practices safeguarding the drug making environment continue to rely on periodic air and a culturing method from a prior century. By Aric Meares, President and CEO, BioVigilant
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Efficiencies Of Natural Convection In Passive Pallet Shippers
Bulk transportation of temperature sensitive pharmaceuticals and biologics has become a common practice due to complex global supply chains. By Iftekhar Ahmed, Ben VanderPlas, and Stu Krupnick
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The Effect Of Non-Specific Interactions On Biomolecular Detection And Analysis
12/30/2012
Non-specific interaction is a very important issue to be concerned in biomolecular detection and analysis, because such interactions can cause false positive results and other interference to the assay.
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Maximizing Cell Growth And Isobutanol Production
4/18/2016
This application note describes the integration of a Thermo Scientific® Prima® dB Mass Spectrometer (MS) with DASGIP Parallel Bioreactor Control Systems implemented at Gevo®, Inc. in Englewood, Colorado. By James Glenn, Claudia M. Huether, and Christiane Schlottbom