AI Webinars
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Maximizing Product Titre By Strategic Control Of Osmolality In Mammalian Cell Bioprocesses
4/30/2021
Osmolality is a key process parameter in mammalian cell bioprocesses that affects both specific cell growth and specific cell productivity. Published data shows that hyperosmolality, used in a targeted way at particular stages of the biological production process, for certain cell types, can enhance final product yield significantly. This presentation reviews the strategies that can be used to manipulate osmolality to increase production yields of monoclonal antibodies and other recombinant proteins.
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Osmolality: A Predictor In Mammalian Cell Culture
4/30/2021
In this presentation we explored the quality and significance of osmolality as a predictor for titer, glucose consumption, and growth-inhibitory by-products such as ammonium in mammalian cell culture. The measurements of different runs were used to establish correlations with osmolality and independent runs to test the predictive power of osmolality. Interestingly the osmolality is a good predictor for glucose, ammonium, and dissolved CO2 among others with a weaker power. The implementation of osmolality measurement and its application in bioprocessing is also discussed.
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Upstream Applications Of Osmolality Testing In Cell & Gene Therapy Processes
4/30/2021
This presentation focuses on the incorporation of osmolality testing into upstream applications which include media development, feeding strategies, and the minimization of aggregation.
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The Future Of Osmolality Testing Within Cell & Gene Therapy
1/4/2021
Learn more about our latest osmometers designed for process development while seamlessly transferring into GMP environments with advanced data management features (21 CFR Part 11) in this presentation, hosted by Kendal Studd, Applications Scientist.
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Osmolality Testing: Providing Unique Process Control For Downstream Operations
12/27/2020
Osmolality serves as a key orthogonal property in downstream processing. This webinar will demonstrate the value of osmolality testing as a key process parameter in buffer preparation, purification, and filtration operations.
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21 CFR Part 11 Compliance And Osmolality As A Process Parameter
12/26/2020
FDA warning letters due to incomplete data in the pharma and biotech industries can be prevented by ensuring the reliability of electronic records, a process known as Compliance with Data Integrity.
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8 Ways That Osmolality Testing Improves Cell And Gene Therapy Process Development And Manufacturing
12/26/2020
Osmolality is a measure of solute concentration and an indication of the solution’s osmotic pressure (USP, EP). It provides the concentration of any solution and has several potential applications within cell and gene therapy development and manufacturing. Learn more about the role osmolality plays in viral vector stability.
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Approaching Digital Transformation: How Biopharm Should Prepare For Validation And Compliance
12/18/2020
As more people, systems and tools consume data, it becomes increasingly valuable because it can be translated into action to improve quality and performance while reducing costs and time to market. However, with additional systems and users comes a risk that, if not managed correctly, can compromise the integrity of data.
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Optimizing Downstream Control With Osmolality Testing
12/18/2020
The bottleneck for real time control and real time release is lack of product-specific in-line sensors or fast at-line methods suitable for model-based prediction of process outcome. There are multiple sensor-based parameters that help monitor a purification process, but which ones serve as predictors for protein concentration?
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New And Revised ISO Standards For Liquid Handling Instruments
Here, we discuss the new series of standards and revisions for automated liquid handing instruments and what they mean for your laboratory.