FEATURED ARTICLES

• Introduction To Tangential Flow Filtration

  Learn about tangential flow filtration (TFF), typical TFF system configurations, ultrafiltration fundamentals, applications, system selection considerations, and more.

• The Identification Of A MicroRNA With A Key Role In Parkinson's Disease

  Learn more about the potential of microRNAs as therapeutic targets being investigated for a number of different disease states.

• Leveraging Filtration Plates To Accelerate The Detection Of Vitamin B6 In Clinical Samples For Research Purposes

  By employing a simple strategy many different lab protocols where filtration is required can be accelerated. Learn more about automation-friendly 96-well filter plates that enable more samples to be filtered in one go.

• Understanding Sterile Filtration And Importance Of Prefiltration

  Learn more on the importance of sterile filtration and how sterile filters are validated by the manufacturer and review the process and value of selecting the best prefilter to improve final sterile filtration performance.

• Western Blotting Principles And Methods

  Western blotting is an established way to detect and analyze proteins. We share the latest expertise and technology to support your success from sample preparation to analysis.

• Supporting Your Data With Traceability, Accountability, And Integrity

  Is gel and blot imaging a part of your workflow? Understand five ways the Amersham ImageQuant™ 800 GxP imaging system helps you remain compliant.

• Do Not Let HCPs Delay Your Biologics Route To Market

  The stakes are high in biologics development, especially in host cell protein (HCP) analysis. See how optimizing your HCP assays can smooth your route to market.

• FAQs: Challenging Host Cell Protein Assays For Improved Risk Mitigation

  Andrew Hamilton, PhD, Scientist, Imaging & Western Blotting, and Joe Hirano, PhD, Program Manager, Imaging & Western Blotting, answer top questions about challenging host cell protein assays.

• Confidence In HCP Coverage Assays With Differential Gel Approaches

  With more than 20 years of expertise, Cytiva's consumables were developed to support 2D electrophoresis for HCP coverage and give you a solution that provides the highest sensitivity and resolution.

• Future-Proof Your HCP Strategy

  Walk through four questions to help you decide if your HCP analysis data is accurate, robust, and ready for next phase approval.

• Strategy For Host Cell Protein Control

  Critical aspects of therapeutic development and manufacture are host cell protein (HCP) detection, quantitation, and removal from drug substances, to ensure efficacy and prevent immunogenicity. 

• Controlling Host Cell Proteins In Drug Development

  Explore methods to detect HCPs and how to reduce the risk of unexpected HCPs and maximize the efficiency of your HCP management strategy.

• Quantify And Characterize Host Cell Protein With Confidence

  Robust solutions deliver accurate results to prevent HCP underestimation and maintain the pace of biopharmaceuticals development and production.

• Ultrafiltration Devices And Plates Offer Higher-Throughput Options For Cloning And PCR Workflows

  Learn how ultrafiltration devices in various steps of the cloning workflow can provide a more streamlined process compared to traditional methods of subcloning PCR-generated fragments.

• Diafiltration: Efficient Desalting, Buffer Exchange Of Biologic Samples

  This article covers the concepts of protein concentration and diafiltration, comparing different ways of performing diafiltration and their impact on process time, volume, product stability, and recovery.

• The Impact Of Fine Particle Matter Beyond Respiratory Health

  Although it is still challenging to gauge the full extent of the consequences of air pollution, governments around the world are starting to recognize the seriousness of this problem, introducing measures to curb pollution. However, considerable progress is still needed, and PM_2.5 particles (those ≤2.5 µm) are of particular concern, not just in respiratory health but in a wider context.

• Report: Trends In HPLC Sample Preparation

  This report summarizes the results of an anonymous online survey conducted by The Analytical Scientist (Texere Publishing) on behalf of Cytiva. The intent was to learn more about the needs and preferences of individuals who were involved with high-performance liquid chromatography (HPLC) sample preparation.

• To Filter Or Not To Filter In HPLC? Now, That's A Question.

  How do you use filtration in HPLC? Why might you not use filtration in HPLC sample prep and in-system, and when is it essential? And how can syringeless filters simplify your workflow, saving resources and time? Let’s find out.

• How-To-Guide: Multiplexing Your Lateral Flow Assay

  There are numerous reasons why combining detection of multiple targets within a single assay is desirable. This guide outlines some of the important factors to consider when developing a multiplex LFA, be it from scratch or building on previously developed singleplex assays.

• Whatman Paper Filtration 101 – Part 3: Folding

  Part 3 of this series describes various filter paper cone folding techniques. Read on to see the options for getting a good seal over your conical funnel.