Article | January 1, 2022

Quantify And Characterize Host Cell Protein With Confidence

Source: Cytiva
iStock-861606270-scientist-lab-DNA

Chinese hamster ovary (CHO) cells are a widely used system to produce recombinant proteins via cell culture, but this approach has a major caveat: these host cells also produce various proteins to support normal cell growth, survival and proliferation.

These host cell proteins (HCPs) pose a risk for immunogenicity of biotherapeutic products and must be reduced to sufficiently low levels to ensure safety and efficacy. Relying on inadequate HCP detection methods can create additional costs and significant project delays, as the discovery of unexpected HCP levels in later clinical trial phases necessitates a redesign of the purification strategy.

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