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By Vadim Klyushnichenko, Ph.D., Calibr-Skaggs Institute for Innovative Medicines | This emerging class brings substantial formulation challenges beyond those of traditional mAbs. Here’s a comprehensive look at the issues and some solutions. | |
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| Webinar: Seals & Stability: Preventing Failures in Synthesis and Chromatography Columns | This webinar highlights the overlooked importance of seals and O-rings in oligonucleotide synthesis and chromatography. Chuck Haeger shares real-world cases showing how proper maintenance and skilled teams prevent failures. Attendees will learn strategies to boost column longevity, reduce risks, and ensure high-quality output—ultimately supporting the production of life-changing medicines. Click here to learn more. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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By Bioprocess Online Live | The structural complexity and variability of multispecific molecules presented purification challenges, from incorrect chain pairings to increased aggregation, fragmentation, and lower yield compared to standard mAbs. Developers shared how they overcame these challenges to achieve high purity and discussed key considerations for downstream developers when designing these processes. Bioprocess Online editor Tyler Menichiello explored these questions with Jian Ren, Ph.D., a principal scientist in downstream process development at AbbVie, and Mark Fitchmun, founder, president, and CEO of Somatek. | |
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| Shear and Flow In High-Productivity Membrane Affinity Chromatography | Application Note | By Eric Van Voorhees, Hasan Hashemisohi, Ph.D., W.L. Gore and Associates, Inc. and Neha Saxena, Ph.D., Shunsuke Shiina, Ph.D., Rodrigo Gonzalez, Ph.D., AGC Biologics | Can high flow rates and turbulent conditions compromise protein quality? This analysis explores the relationship between fluid dynamics and aggregation in membrane and resin chromatography systems. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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