Newsletter | May 5, 2025

05.05.25 -- Process Optimization Or Full-Scale Automation?

SPONSOR

Explore the latest biotech equipment and solutions — all online, wherever you are.

Don't miss the next Bio-Expo Live! This interactive, multi-day event is organized by stages of drug development and production, making it easy to find sessions tailored to your company's needs. Browse the full agenda and register for free to join the conversations most relevant to your work.

FOCUS ON UPSTREAM MANUFACTURING

Process Optimization Or Full-Scale Automation?

While continuous processing often steals the spotlight with its promise of uninterrupted workflows, many seasoned professionals continue to advocate for process optimization and intensification as equally effective—and far less capital-intensive—alternatives.

From BPI West: An Upstream Scientist's Advice On Target Glycosylation

Bioprocess Online spoke to an upstream scientist at Bristol Myers Squibb during this year's BPI West. Here's what he had to say.

Using AI And ML To Gain Insight Into Optimal Glycoforms

Bioprocess Online asked Nathan Lewis, Ph.D., to briefly explain the research he presented at BPI West 2025.

Cancer Immunotherapy: Engineered Immune Cells For Anti-Tumor Immunity

Learn in detail about cell-based cancer immunotherapy, including techniques for engineering immune cells and methods used for manufacturing genetically modified cells that are currently in practice.

A Deep Dive Into Expression Approaches For Biotherapeutics

Whether you’re at the discovery stage or thinking about commercial production, gain useful insights on expression formats from transient transfection, through stable pools to stable clones.

Suspension Culture Enables Expansion, Differentiation Of PSCs

Explore the use of 3D cell culture to increase the clinical production of stem cells. By culturing cells on microcarriers, researchers can retain typical stem cell characteristics while increasing production.

Performance Of DMSO-Free Cryopreservation Media Formulation

Cryopreservation enables cell therapy by storing cells long-term. A DMSO-free formula preserves cell viability and health, minimizing toxicities linked with traditional cryoprotectants.

Elevating AAV Manufacturing With Tailored Cell Lines

Skillfully crafted cell lines can substantially enhance vector purity and yield. Watch to explore a portfolio of engineered cell lines and their potential to transform the landscape of AAV production.

Technologies Transforming Upstream Process Intensification

The need for intensified cell culture technologies is being met by perfusion using alternating tangential flow (ATF), which has emerged as a leading solution to increase cell density and productivity.

Increasing Titer In Biologics Manufacturing With Fed-Batch Intensification

Learn how the advanced principles of process intensification can be applied to process and equipment design, increasing facility throughput, and ultimately offering a wide range of benefits to customers.

Enabling Rapid, High-Yielding, Stable Cell Line Development

Discover how to simplify and accelerate CHO-S stable cell line development, eliminating the need for extensive screening of candidate clones and specialized equipment.

Multiplex Imaging

Explore recombinant antibody reagents that support the imaging of key targets within the TME and offer flexible solutions across various platforms to improve patient outcomes.

Cracking The Reproducibility Code: Sera Is A Key Component

Struggling with reproducible cell culture results? Sera variability is a major culprit. Learn how to choose the right sera, test lots, and stock up to ensure consistency and boost reproducibility.

Optimizing T-Cell Expansion Using DoE And Process Transfer

Manufacturing CAR-T cells is challenging, but crucial. Discover how stirred culture systems paired with an innovative platform and software can accelerate development and enhance process understanding.

SPONSOR

Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific.

UPSTREAM MANUFACTURING SOLUTIONS

Cell Line Development For Biologics CHO CLD Platforms - Aragen Bioscience, Inc.

CRISPR From Research To Therapy - Lonza

Next Generation Superior Cellulose Membrane - Asahi Kasei Bioprocess

Hold-Up Volume And Sterile Filtration Solutions - Entegris, Inc.

Connect With Bioprocess Online: