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| Regulators are shifting the biosimilar approval paradigm — prioritizing deep process understanding over large clinical trials. In this evolving landscape, defining and controlling CPPs is essential to demonstrating high similarity. Join Bioprocess Online’s Jon O’Connell on March 24th at 11 am Eastern for a live Q&A with Sarfaraz Niazi, Ph.D., Vince Narbut, and Diana Colleluori, Ph.D., as they explore how QbD and CQA insight can streamline development and regulatory success. Register for free today thanks to support from sponsor Cytiva. |
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FOCUS ON UPSTREAM MANUFACTURING |
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By Bioprocess Online Live | In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists discuss where they see the greatest opportunities for teams to reduce COGs and advise teams to take a holistic approach to cost reduction. | |
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| What Is Transfection? | Article | Mirus Bio | Learn about the process of transfection and why it is crucial for studying gene function and has applications in various fields, including drug development and gene therapy. |
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| Cell Line Development For Bispecific Antibodies | White Paper | By Sowmya Rajendran, Indira Kottaiyl, Lynn Webster, et al., ATUM | See how the recently described cell line development paradigm shift, enabled by an innovative platform, can extend to the development of bispecific monoclonal antibody-producing cell substrates. |
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| CAR Expression Detection Using Fluorescent Labeled Proteins | Application Note | By Siqi Huang, Xiaojuan Shi, Yanke Liu, Jane Liu, Spencer Chiang, ACROBiosystems | Learn how site-specific fluorescent labeling addresses key challenges in flow cytometry-based evaluations by enhancing assay sensitivity, reducing variability, and ensuring reliable results. |
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| Chemically Defined HEK293 Viral Feed Boosts Viral Vector Production | Poster | By Shan Gao, Hamid Soleymani, Shahram Shahabi, et al., FUJIFILM Biosciences | Examine how a chemically defined viral feed can boost AAV titers by up to 8-fold, supporting multiple serotypes and both suspension and adherent HEK293 cell lines, simplifying scalability. |
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| A Smart Path For Novel Biologics | Article | By Pawel Linke and Markus Neubauer, Roche CustomBiotech | Read about a solution for streamlining workflow in novel biologics while collecting quality data, by combining single-use microbioreactors with advanced automation and analytical platforms. |
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| Webinar: Defined Media, Defined Results: Scaling E. coli from Bench to Fermenter | Microbial systems power plasmid DNA and recombinant protein production, but scaling introduces variability. This webinar explores how chemically defined media can improve performance, reproducibility, and animal-origin-free workflows. Experts share beta-test results from E. coli cultures using defined formulations, plus practical insights on integrating them into workflows and scaling from experiments to fermenter production for reliable manufacturing outcomes. Click here to learn more. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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