Implementing Raman Spectroscopy For Automated Monitoring Of A Cell Culture Bioprocess

Raman spectroscopy offers a "molecular fingerprint" for real-time analysis of bioprocess parameters, providing critical information about viable and total cell density, protein titer, and key nutrients like glucose and lactate. Building robust chemometric models for this technology requires a substantial number of experimental data points, often obtained through alternative analytical methods.

This application note describes an efficient approach to acquiring such data by conducting four bioprocesses in parallel using SciVario® twin bioreactor control systems equipped with a multi-channel ProCellics® Raman Analyzer. Discover how this setup facilitates rapid model development and real-time monitoring of CHO cell fed-batch processes by reading the complete application note.