Newsletter | May 12, 2025

05.12.25 -- Common Manufacturing Challenges For LBP Formulations

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CHOZN® GS-/- Perfusion Cell Line Development for Intensified Processes

Discover how an optimized cell line development workflow can enhance productivity in continuous bioprocesses. Pairing the CHOZN® GS-/- cell line with chemically defined media in an advanced microbioreactor system can boost specific productivity and overall yields. Download our white paper to explore strategies for improving biomanufacturing efficiency to meet the growing demands of the biopharmaceutical industry. Download the white paper here.

FOCUS ON UPSTREAM MANUFACTURING

Common Manufacturing Challenges For LBP Formulations

As more companies explore live biotherapeutic products, ensuring stability is likely to be front and center with unique challenges for oral and topical applications.

Achieving Optimal Cell Harvest With Purpose-Built Harvest Technologies

For many applications, cutting-edge centrifugation technologies can achieve cell harvest optimization, providing a low-shear, high-yield process that is tightly controlled and highly reproducible.

The Immortal Question: Can MSCs Be "Like A Cell Line But Not A Cell Line?"

Mesenchymal Stem Cells (MSCs) hold immense therapeutic promise. Can we harness their potential by making them more like consistent cell lines, without losing their unique advantages? Let's explore.

Bioprocess Operation Modes And Advanced Bioreactor Technologies

Explore innovative cell culture methodologies and bioreactor technologies to optimize productivity, enhance product quality, and drive efficiency in biotechnological applications.

Mixing Of Various Dry Powdered Media And Buffers

Learn how a mixing system that efficiently handles various powdered media and buffers, ensuring precise solubilization and mixing in applications like cell culture and protein purification.

Generation Of Stable CHO Cell Lines For Protein Production

By following the five steps of a specialized protocol, exceptional yields and stable cell lines can be achieved in CHO cells using antibiotic selection.

Transforming Data Into Knowledge Throughout The Product Lifecycle

Explore process characterization services based on QbD principles, with an emphasis on risk and knowledge management and transforming data into the currency of product and process knowledge.

Stable Bulk Cultures: A Fast Path To Antibody Manufacturing

The potential advantages that stable bulk cultures can offer a drug development paradigm are poised to accelerate and bolster biopharmaceutical clinical manufacturing.

Why Use Transposase Technology For Expression Of Your Biotherapeutics?

Discover how a proprietary transposase technology works and why it can be beneficial for the development process for the expression of biologics.

Streamlining Mesenchymal Stem Cell (MSC) Expansion

A new functionally-closed cell expansion system featuring a hollow-fiber membrane and customizable protocols is streamlining the production of stem cells for regenerative medicine.

Overcoming Barriers To Membrane Technology

Uncover how the interchangeable use of Protein A membrane and resin media can streamline your bioprocessing workflows, ensuring efficient, scalable, and high-quality manufacturing.

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Webinar: Maximizing Media Strategies: Insights on Boosting Performance

Join our live virtual roundtable on biopharmaceutical production! We'll discuss media formats, taming variability, and analytics for performance optimization. Experts will cover topics like bioprocess development, actionable analytics, and using quality attributes for scale-up decisions. Submit your questions anonymously in advance or during the event. Don’t miss out—register today! Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

ELEVECTA Producer Cell Line For Stable, Inducible AAV Production - Cytiva

CytoPak Products: Closed Process Solutions For Cell Therapy - ACROBiosystems

Getting Started With Vertical-Wheel Bioreactors - PBS Biotech, Inc.

Your Global Network For Mammalian Cell Culture Manufacturing - Boehringer Ingelheim Biopharmaceuticals GmbH

Labfors Bench-Top Bioreactor For Solid Substrates, Enzymatic Bioprocesses - INFORS HT

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Webinar: Peptones and Vaccines: A Synergistic Approach to Enhanced Production and Efficiency

Discover how peptones can enhance vaccine production efficiency in this Thermo Fisher Scientific webinar. Learn how these versatile, cost-effective supplements support cell growth, viral production, and overall performance while reducing costs. Explore real-world data showcasing productivity gains and gain strategies for integrating peptones into your vaccine workflow to streamline development and accelerate market readiness. Click here to learn more.

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Multispecific molecules bring added complexity to downstream purification—think incorrect chain pairings, aggregation, fragmentation, and lower yields. Join Bioprocess Online Live as we explore how developers are addressing these challenges to achieve high purity and efficient processes. Gain insights into key considerations for downstream teams when designing purification strategies for these advanced biologics. Registration is free thanks to the support of Thermo Fisher Scientific.

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