Why Use GS piggyBac® Transposase Technology For Expression Of Your Biotherapeutics?

In this interview, Dr. Peter O'Callaghan discusses Lonza's GS piggyBac transposase technology, which involves the use of transposase enzymes to insert genes of interest into host cells. This technology allows for stable and high expression of biologics.

One of the main advantages of using GS piggyBac is faster recovery post-transfection, meaning that the cells can resume normal growth and productivity more quickly. Additionally, the technology allows for higher average titers, which refers to the amount of product that can be produced by the cells. This is beneficial for increasing the yield of biologics.

Another advantage of GS piggyBac is that it can support transient screening of therapeutic candidates. This means that researchers can easily test different genes or combinations of genes to identify the most effective therapeutic candidates.

One of the notable features of GS piggyBac is that there is no size limit for the genes that can be inserted. This means that even large genes can be efficiently inserted into the host cells using this technology. The GS piggyBac transposase technology offered by Lonza provides a versatile and efficient method for inserting genes of interest into host cells, allowing for stable and high expression of biologics.