Newsletter | August 4, 2025

08.04.25 -- Closed-Loop Manufacturing Is The Cell Therapy Revolution We Need

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Webinar: Efficient Scale-Up of Monoclonal Antibody Production: From Bench Top to 500L

Join Thermo Fisher Scientific for a live webinar on scaling Herceptin production in CHO-K1 cells from 3L to 500L using HyPerforma™ and DynaDrive™ bioreactors with Gibco™ Efficient-Pro™ media. Discover how consistent productivity and product quality were maintained across scales, supported by a streamlined downstream process. Gain valuable insights into efficient, scalable monoclonal antibody (mAb) production. Click here to learn more.

FOCUS ON UPSTREAM MANUFACTURING

Functional Antibody Screening With Abalone Bio's Richard Yu, Ph.D.

In this episode of "Better Biopharma," Abalone Bio's CEO and co-founder, Richard Yu, Ph.D., explains how the company's functional antibody selection technology (FAST) platform differs from traditional affinity screening.

Closed-Loop Manufacturing Is The Cell Therapy Revolution We Need

In cell therapy manufacturing, automated closed systems with integrated software controls offer numerous benefits over traditional open systems.

Rapid Discovery Of CD200R1 Antagonist VHHs Via Single B Cell Technology

Learn about the use of a single B cell antibody discovery to identify a set of high-affinity, neutralizing VHH from immunized llamas against CD200R1, an emerging therapeutic immune checkpoint target.

The Shear Problem Facing Cell Separation

Explore the significance of low-shear separation and delve into the principles of tubular bowl centrifugation, comparing it to alternative technologies.

CHO Cell Lines For Recombinant Protein Production

Discover how new strategies in CHO cell line development are driving innovation and transforming the future of biologics manufacturing, from enhanced productivity to improved therapeutic quality.

A Scientist's Roadmap To Scale-Up

Dive into a step-by-step roadmap from candidate generation to GMP production, leveraging incubator shakers and automation for streamlined, high-yielding cell line development.

Achieving Rapid, High-Titer Expression For Next-Generation Biologics

This advanced cell line development technology overcomes production challenges related to the expression and scalability of complex biologics.

Automated Sampling Of A Four Vessel Parallel CHO Cell Culture

Uncover how automated sampling for parallel bioreactors enables continuous, sterile sample collection from CHO cell cultures, maintaining cell density with reduced manual intervention.

Suspension Culture Improves iPSC Expansion And Pluripotency Phenotype

Learn about the advantages of 3D suspension culture for iPSC expansion, including enhanced pluripotency and genetic stability. Discover how this technique yields high-quality iPSCs for regenerative cell therapies.

Achieving Greater Downstream Recovery By Minimizing Upstream Loss

A novel cell lysis solution can improve rAAV recovery by rapidly rupturing cell membranes while remaining compatible with existing workflows. Discover a scalable and efficient lysis alternative.

Accelerating CGTs With Excipient GMP Quality Media And Buffers

The EXCiPACT certification for Excipient GMP quality media and buffers ensures the safety, efficacy, and scalability of cell and gene therapies, accelerating development and improving patient access.

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Webinar: Next-Gen Disease Models & Cell Therapeutics: Innovations in AI, Omics and Collaboration

Join Thermo Fisher Scientific for a webinar exploring how innovations in 3D disease models, multi-omics integration, AI/machine learning, and global collaboration are transforming healthcare. Experts will address regulatory and ethical considerations and strategies for bridging research to clinical application. Learn how these advancements are improving patient outcomes and accelerating the development of personalized therapies. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

CellCube: Enabling Scalable And Efficient MSC Production - Corning Life Sciences

Choosing A Cell Expansion Platform - Terumo BCT

SUREtechnology Platform - KBI Biopharma

Process Analytical Technology For In-line Bioprocess Analysis - Repligen – PAT

GS Effex Cell Line For Enhanced Antibody Effector Function - Lonza

Single-Use Production Reactor Cultivation Container - Getinge

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