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| Finally, a Scalable Weak AEX-HIC Mixed-Mode Resin! | Bio-Rad's new Nuvia wPrime 2A Media is a weak anion exchange-hydrophobic multimodal chromatography resin that offers superior selectivity. The strength of the resin's AEX mode can be modulated to meet your specific needs. With robust chemical and mechanical stability, and reliable and resilient performance, this resin can help improve process economics and productivity while delivering high biomolecule purity and yield at lab-to-process scales. Learn more and request samples. |
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FOCUS ON DOWNSTREAM MANUFACTURING |
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By ASTM International Cleaning Standards Team | This article provides an update on the progress of the science-, risk-, and statistics-based ASTM International Cleaning Standards: published standards, work currently underway, and how you can get involved. | |
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| Eliminate Downstream Bottlenecks In Antibody-Based Therapies | Article | By William Barrett, W.L. Gore and Chase Snyder, AGC Biologics | Organizations seeking greater efficiency within their downstream purification processes are well-served in considering a single-use, membrane-based solution in lieu of resin-based purification columns. |
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| Optimizing Time And Cost Efficiency In Cell Line Development | Application Note | By Hannes Korndörfer, Heiko Dinter, Magnus Warnke, Alexandra Stützer, and James Edwards, Sartorius | Discover a system that automates mAb purification, reducing time and costs in cell line development while improving reproducibility, with faster processing than traditional methods. |
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| A Guide To Scaling Protein Purification | e-book | Ecolab, Purolite Resins | Discover the essentials of scaling protein purification and tackling challenges like purity, cost-efficiency, and scalability. Gain practical strategies and solutions to achieve reproducible, scalable results. |
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| Alternative Two-Step Mixed-Mode Approach To A mAb Purification Process | Application Note | By Sharon Bola, Jamie Greenwood II, William Rushton, and Mackenzie Scherr, Bio-Rad Laboratories, Inc. | Two post–Protein A capture two-step mAb processes were developed and compared to an archetypical three-step mAb purification process using two IEX steps after Protein A capture. |
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| Risk Control | Bulk Filling Application | Webinar | Cytiva | Learn about a bulk filling system that enables you to achieve risk control, accuracy, and superior product recovery in your fill and finish operations. |
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| Predicting Viral Clearance In Downstream Process Development | Application Note | By David Cetlin, Cygnus Technologies Inc. | Optimize purification steps and determine with confidence whether process steps and parameters are effective before investing resources in regulatory supporting validation studies using live virus. |
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| Designing Successful Viral Clearance Studies | White Paper | By Kathryn Martin Remington, Ph.D. and Kate Smith, MilliporeSigma | Review studies that involve scaling down individual process steps, and for each step, spiking virus into the specific process intermediate, performing the process step, and measuring the remaining virus. |
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DOWNSTREAM MANUFACTURING SOLUTIONS |
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| Overcoming Challenges In CGT Development | Webinar | CPC | Explore connector solutions for sterility, chemical compatibility, and ultra-low temperature challenges when setting up a therapeutic process for long-term success. |
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| Vial Containment Systems Based On Elastomer 4031/45 Gray | Article | By T. Page McAndrew, Ph.D. and Victoria Morgan, West Pharmaceutical Services, Inc. | For a properly-assembled vial containment system, good container closure integrity performance can be achieved with stoppers of a given elastomer, independent of configuration. |
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