Newsletter | September 21, 2026

09.21.26 -- A Gentler Cell Line Selection Method Using microRNA

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The body as a bioreactor

What if therapeutic production could move from the facility into the patient? Explore how advances in lipid nanoparticle design, delivery science, and manufacturing are helping bring the body-as-a-bioreactor vision closer to reality—and reshaping what may be possible for genomic medicine.

FOCUS ON UPSTREAM MANUFACTURING

A Gentler Cell Line Selection Method Using microRNA

Traditional selection stresses surviving cells. New research shows how structurally interacting RNA may use endogenous microRNA for a faster, nontoxic selection process.

 

 

The Difference Between Batch, Fed-Batch, And Continuous Processes

Feeding strategy directly influences growth, yield, oxygen demand, and product quality. Choosing the right mode—batch, fed-batch, or continuous—helps balance productivity, control, and efficiency.

 

Efficient Clone Screening With Increased Process Control

Automated screening of antibody-producing clones provides real-time cell health and titer data, helping developers identify top-performing candidates earlier and with confidence.

 

Enhancing AAV Manufacturing Yield Via Mini-Helper Plasmid

Learn how rational plasmid engineering and promoter optimization can significantly improve AAV productivity while reducing plasmid burden, paving the way for more efficient manufacturing.

 

Unlocking ROI And Capacity In Monoclonal Antibody Manufacturing

Perfusion-based upstream production offers up to 24% lower cost and significantly higher productivity than fed-batch, enabling faster timelines, better facility utilization, and improved quality.

 

Optimization Of Transient Protein Expression In CHO Cells

Gain insight into a set of optimized transient expression tools to support early stage expression of a range of therapeutic proteins.

 

Media Exchange In iPSC Cell Expansion And Differentiation

Low-shear, closed-system media exchange is vital for scalability. This study compares automated centrifugation to gravity sedimentation, showing equivalent or superior differentiation outcomes.

 

Cell-Based Screening: Accelerating Therapeutic Development

Discover how advanced transfection technology can accelerate therapeutic development, as well as faster, more flexible cell-based screening assays to optimize your research.

 

Scalable Biologics Production Trends: Featuring Omar Wahab

Listen in as Dr. Corey Stanton speaks with Dr. Omar Wahab, Vice President of Bioprocessing at Lonza, about the strategic role of cell culture media in scalable biologics manufacturing.

 

Recombinant Erwinia Asparaginase Production

When E. coli-derived asparaginase supply failed patients with hypersensitivity, a recombinant Erwinia alternative went from project kick-off to FDA approval in approximately five years.

 

Criteria For Effective Bioprocess Scale-Up

Examine four essential bioprocess scale-up criteria and how each balances hydrodynamics, shear, and mass transfer across manufacturing scales.

 

Unlock The Potential Of GPEx Lightning Accelerate Your CLD

See how an advanced cell line development platform now supports HEK cells alongside CHO, enabling rapid, scalable production of complex biologics while saving up to 12 weeks on development timelines.

 

Optimizing Upstream High-Throughput Biologics Development

Watch to understand more about designing large Design-of-Experiment (DOE) upstream process development studies and the elements that could positively or negatively effect your throughput.

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Webinar: Beyond Fed-Batch: Choosing the Right Path to Process Intensification

How can biomanufacturers increase capacity without expanding their footprint? This webinar explores upstream process intensification strategies, from intensified fed-batch to continuous manufacturing. Discover how the right approach can drive 5–10× higher cell densities and 2–10× higher product titers while improving bioreactor utilization. Explore case studies and economic trade-offs to optimize productivity, reduce COGs, and support scalable manufacturing. Click here to learn more.

UPSTREAM MANUFACTURING SOLUTIONS

Cell Culture Media For Viral Vector Production - Cytiva

Exosomes/Extracellular Vesicles - RoosterBio

What Our Partners Achieve With P. fluorescens-Based Expression Technology - Primrose Bio

Next Generation CHO Host To Boost Your Yield - MilliporeSigma

Robust Cell Line Development - ATUM

AAV Edge System - Asimov

Unlock Your Manufacturing Potential With Scalable Glycoengineering - Roche CustomBiotech

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Webinar: Accelerating CHO Media Development: From High-Throughput Screening to AI-Guided Design

Ready to rethink cell culture media development? Discover how high-throughput screening, process analytics, and AI-guided modeling can transform CHO media and feed optimization. This Thermo Fisher Scientific webinar explores ways to reduce experimental burden, navigate complex formulation spaces, and replace trial-and-error with faster, more predictive strategies. Gain practical insights to accelerate development and make smarter, data-driven decisions. Click here to learn more.

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