Efficient Clone Screening With Increased Process Control And Integrated Cell Health And Titer Measurements With The Cydem VT Automated Clone Screening System

By Kathrin Olschok and Noud Drummen, Beckman Coulter Life Sciences

This content is brought to you by Beckman Coulter, a Danaher Operating Company.

Accelerating cell line development requires precise decision-making backed by high-density, reliable data. Parallel screening of up to 96 antibody-producing clones under tightly controlled environmental conditions provides critical insights into growth rates, viability, and product yield. Automatically tracking cell health metrics alongside real-time titer measurements captures subtle variations in performance that might otherwise be missed with infrequent offline sampling.

For example, understanding when specific clones accelerate antibody production allows developers to identify top-performing candidates early and with greater confidence. High correlation between automated online tracking and traditional offline analysis confirms that integrated workflows maintain high accuracy while significantly reducing manual labor. Implementing these automated parameters, from individual gassing control to scheduled feeding, ensures robust process control throughout a multi-day fed-batch cultivation.

Explore how automated screening can optimize your cell line development workflow by reading the full application note.