What Our Partners Achieve With Pfenex Expression Technology

Insufficient yield, inactive protein, and expression systems that can't handle difficult modalities are problems R&D and lead-ID teams encounter repeatedly. Pfenex Expression Technology, built on Pseudomonas fluorescens native biology, is designed to address exactly these failure points. High-density, defined-media processes routinely deliver double-digit gram-per-liter titers, with documented 10-20x improvements over E. coli, CHO, and yeast for the same target. Periplasmic localization supports disulfide bond formation and reduces proteolytic clipping, generating soluble, active protein without a refold step.

With 6 approved products and 25+ technology transfers behind it, the platform has been validated across antibody fragments, vaccine antigens, therapeutic enzymes, peptides, cytokines, and engineered multivalent binders. Download the brochure to learn more.