DISCOVERY
The NanoAssemblr® Spark™ Robust Low Volume RNA-Lipid Nanoparticle Formulation
Develop RNA-lipid nanoparticles (LNPs) in under 10 seconds for drug discovery and early preclinical development. The NanoAssemblr®️ Spark™ instrument enables rapid µL formulations to conserve limited and expensive ingredients with minimal waste....
RNA Delivery Business with Liberate's Shawn Davis, Ph.D. & Walter Strapps, Ph.D.
Earlier this year, Shawn Davis, Ph.D. left a pretty comfortable position at AstraZeneca (and Amgen before that, and Milliken – and others – before that) to lead Liberate Bio. He brought along another industry notable in Merck/Intellia alumnus Walter Strapps,&n...
Elucidating The Role Of IL-18 In NSCLC Integrated Analysis
Hear how imaging mass cytometry, CyTOF, and single-cell sequencing unlock the secrets of the tumor microenvironment. Discover new insights into IL-18 and its impact on non-small cell lung cancer.
Validation Of An LCMS Hybrid Assay With EVOSEP Cleanup
By leveraging this innovative combination, the assay achieves detection limits comparable to traditional methodologies while enhancing overall efficiency and reliability.
LC/MS/MS Analysis Of Coproporphyrin 1, Coproporphyrin 3 In Human Plasma
This innovative approach holds promise for reducing the need for extensive clinical drug-drug interaction studies, potentially streamlining the drug development process.
BoB@JPM: Gene Writing With Tessera's Michael Severino, M.D.
Flagship Pioneering plucked Michael Severino, M.D. away from AbbVie to run point at Tessera, a startup it's backed to pioneer a new category of genetic medicine it calls gene writing. The Business of Biotech caught up with Severino at the JP Morgan Healthcare Con...
LC/MS Method For Measurement In Human Plasma
According to the researchers, this plasma-based measurement has the potential to serve as a critical pharmacodynamic biomarker, facilitating the assessment of novel therapeutic approaches.
Development Of A Mitra Tip Extraction Assay Coupled With LC-MSMS
Watch this rundown of a novel method for quantifying L-Citrulline, L-Arginine, and L-Argininosuccinic acid using Mitra tip extraction coupled with LC-MS/MS for enhanced accuracy and reproducibility.
Meet Your Bioprocess Sidekick For Cell Culture Media Analysis
You need rapid and reliable nutrient profiles to make informed decisions, and waiting on that data has detrimental effects on your process. See how REBEL fills the gap.
Is The Sensitivity Of Optical Biosensors Important?
Explore why the sensitivity of optical biosensors is important for not just small molecules or fragment-based interactions but also for larger molecular entities.
Is Evaporation Important For Optical Biosensors?
If your sample is open to evaporation effects causing your concentration to change, will your data, and potentially your conclusions, be unreliable?
Nanoassemblr Blaze mRNA Vaccine Demo
NxGen Technology delivers a scalable means to perform the critical particle formation step in a nanomedicine development process.
A Derivatization-Free LCMS Assay For 4β-hydroxycholesterol
Learn about a novel LCMS assay for 4β-hydroxycholesterol, a key biomarker for CYP3A activity. This derivatization-free method offers a faster and more efficient approach for clinical studies.
GLP And The Impact To Start Up Companies
Good Laboratory Practice is often used in laboratories and is necessary for specific investigations. What does it mean? And how can it help start-up companies? Watch this video to learn more.
Tissue Adenosine Distribution-Guided Gene Selection
Unlike conventional predictive biomarkers, which often focus on isolated molecular markers, this strategy integrates spatial metabolomics and genomics, providing a multidimensional perspective.
STUDIUS™ & ICON™: Data-Driven Workflow For The Development Of Modern Cell-Based Therapies
Learn how these two new products work to provide a new data-driven workflow for the development of modern cell-based therapies.
Droplet Digital PCR Systems
Droplet Digital PCR (ddPCR) simplifies the quantification of host cell DNA in process development, quality control, and biomanufacturing processes.
How To Best Optimize mRNA Production Workflows
Multiple steps in the mRNA manufacturing process can appear more complex than they have to be. Learn how to simplify your approach and produce the best possible mRNA vaccines and therapeutics.
Can Kinetics Provide Detailed Information About Binding Interactions?
See the potential value kinetics brings to deepen the understanding of biological processes.
Pragmatic Computational Biology with Andrew Satz
This week's guest on the Business of Biotech, EVQLV's Andrew Satz, says AI and ML in biopharma are like sex in high school. "Many of the people who say they're doing it really aren't, and the one who really are aren't talking about it," he sa...
Antisense Oligonucleotide Extraction Optimization Reveals Differences
Our findings provide critical insights into refining ASO extraction protocols, which can enhance the accuracy of downstream analyses and support further research into ASO-based therapeutics.
Bio & The Business Of Aging with Life Biosciences' Jerry McLaughlin
Core to the clinical-stage biopharma Life Biosciences belief set is that "contrary to popular belief, aging is not caused by random wear and tear, but instead is caused by a discrete set of biological mechanisms that can be targeted therapeutically.”
The NanoAssemblr® Spark™ Instrument Demo
The NanoAssemblr® Spark™ uses proprietary microfluidics technology for the controlled and reproducible manufacturing of nanoparticles in small volumes in less than 10 seconds.
Bio Career Moves With Codagenix's Johanna Kaufmann, Ph.D.
On this week's episode of the Business of Biotech, Dr. Johanna Kaufmann gives us an intimate retrospective on her career to date, sharing stories about her rapid ascension from Scientist 1 to executive leadership. We dig into her wild ride through M&A, her time at...
Saudi Arabia Government Leaders Discuss Agile Manufacturing Beyond Borders
Learn how government leaders in Saudi Arabia planned for biopharma resilience beyond borders and used agile manufacturing to prepare for the unknown.
Droplet Digital PCR For Host Residual DNA Quantification
In this presentation principal scientist for Merck Research Laboratories Dr. Hussain, discusses an extraction-free method in which samples are subjected to digital PCR.
Can You Run Crude Samples Using An SPR Instrument?
We explore a common misconception and provide examples of complex material being used in an SPR system.
Testing Liquid Handler Performance With PCRMix
We demonstrate the importance of using an appropriate test solution when optimizing a liquid handler to dispense the master mix, a critical component in any PCR-based assay.
Don't Be A D**k With Ochre Bio's Dr. Quin Wills
Don't be offended by the title of today's Business of Biotech podcast. Dr. Quin Wills' application of what's become known as "Wheaton's Law" (look it up) is central to the ambitious goals his company, Ochre Bio, is pursuing: pioneering the va...