Discovery STREAM

1. Is Evaporation Important For Optical Biosensors? 2/17/2022

   If your sample is open to evaporation effects causing your concentration to change, will your data, and potentially your conclusions, be unreliable?

2. Don't Be A D**k With Ochre Bio's Dr. Quin Wills 9/27/2023

   Don't be offended by the title of today's Business of Biotech podcast. Dr. Quin Wills' application of what's become known as "Wheaton's Law" (look it up) is central to the ambitious goals his company, Ochre Bio, is pursuing: pioneering the value of computational biology in large mol discovery and development, putting an end to the global liver disease epidemic, and changing the costly, high-risk approach to clinical trials. On this week's episode, Dr. Wills and I explore how those goals are being addressed despite the challenges they present, and how the company's three guiding principles, don't be a d**k being one of them, align the Ochre team with the mission at hand. 

3. GLP And The Impact To Start Up Companies 4/18/2022

   Good Laboratory Practice is often used in laboratories and is necessary for specific investigations. What does it mean? And how can it help start-up companies? Watch this video to learn more.

4. LC/MS Method For Measurement In Human Plasma 2/17/2025

   According to the researchers, this plasma-based measurement has the potential to serve as a critical pharmacodynamic biomarker, facilitating the assessment of novel therapeutic approaches.

5. Can Kinetics Provide Detailed Information About Binding Interactions? 2/17/2022

   See the potential value kinetics brings to deepen the understanding of biological processes.

6. Can You Run Crude Samples Using An SPR Instrument? 2/17/2022

   We explore a common misconception and provide examples of complex material being used in an SPR system.

7. A Derivatization-Free LCMS Assay For 4β-hydroxycholesterol 1/23/2025

   Learn about a novel LCMS assay for 4β-hydroxycholesterol, a key biomarker for CYP3A activity. This derivatization-free method offers a faster and more efficient approach for clinical studies.

8. Antisense Oligonucleotide Extraction Optimization Reveals Differences 2/17/2025

   Our findings provide critical insights into refining ASO extraction protocols, which can enhance the accuracy of downstream analyses and support further research into ASO-based therapeutics.

9. How J&J Is Tackling Alzheimer's Disease With Fiona Elwood, Ph.D. 9/22/2025

   Fiona Elwood, Ph.D., VP and Neurodegeneration Disease Area Stronghold Leader at Johnson & Johnson, explains the company’s modality-agnostic approach to treating Alzheimer’s disease in this episode of Better Biopharma.

10. Functional Antibody Screening With Abalone Bio's Richard Yu, Ph.D. 7/29/2025

    In this episode of "Better Biopharma," Abalone Bio's CEO and co-founder, Richard Yu, Ph.D., explains how the company's functional antibody selection technology (FAST) platform differs from traditional affinity screening.