Downstream Processing

1. Advancing The Purification Of VSV-G Pseudotyped Lentiviral Vector 6/9/2025

   Discover new strategies to overcome lentiviral purification challenges with a scalable approach that maintains viral infectivity through gentle processing conditions.

2. Thermo Fisher Scientific Single-Use Global Manufacturing Network 4/18/2022

   We have implemented a multi-tier strategy to improve the resiliency of our supply chain and created the largest networked single-use manufacturing organization in the world.

3. Addressing Post-Translational Modifications In Novel Protein Therapeutics 9/13/2024

   Meinhard Hasslacher, Ph.D., Head of CMC at SOTIO Biotech, addresses an audience question on conjugation efficiencies in this segment of the Bioprocess Online Live event Early Process Considerations For Novel Protein Therapeutics. From there, we move on to an audience-led discussion on when to initially address titer, PTMS, and product quality during development of novel protein therapeutic cell lines, with Lena Tholen, Ph.D, Director of Cell Line and Bioprocess Development at FyoniBio and Neeraj Pakala, Ph.D. SVP of Product Development and Manufacturing at Vera Therapeutics weighing in.

4. CaptureSelect Affinity Chromatography 11/4/2025

   30-second video sharing a visualization of our CaptureSelect affinity chromatography capability. The target protein binds with VHH molecules immobilized on the chromatography beads, non-target proteins are removed, and the eluted fraction contains a high yield of purified target protein.

5. Beyond Standard Protein A Resin 6/2/2025

   In this study, mAbCapture C affinity resin has been compared with a Protein A resin used in a DSP platform, showing a higher dynamic binding capacity while keeping the product’s critical quality attributes within acceptable limits.

6. CaptureSelect™ Technology - Powerful Affinity For More Streamlined Purification 11/4/2025

   Replace inefficient chromatographic steps with high-specificity affinity ligands to streamline downstream processing. This approach simplifies workflows and protects sensitive biomolecules.

7. Rethinking Sustainability In Bioprocessing 5/22/2025

   Discover how sustainability is transforming bioprocessing through innovative single-use technologies that help reduce environmental impact and support responsible, forward-thinking biomanufacturing.

8. Advancing Gene Therapy Development With A Multi-Serotype AAV Resin 5/29/2025

   In this webinar, leading CDMO ABL and Thermo Fisher will share data on implementation of the POROS™ CaptureSelect™ AAVX affinity resin into such an AAV purification platform, including its performance in purifying several serotypes.

9. The Way Forward: Supply Chain Solutions 10/24/2024

   Learn how to build a resilient supply chain to navigate today's complex environment. Expert speakers share insights on optimization, innovation, and strategic planning to meet evolving market conditions.

10. Accelerating mAb Process Development In The Growing Therapeutics Market 8/20/2024

    The market for mAbs and mAb variants is growing rapidly. Explore the latest strategies and advancements in early stage mAb up- and downstream process development.