Featured Articles

  1. mRNA Process And Cost Modeling: A Tool To Optimize Process Development 3/10/2023

    Demand for mRNA-based medicine production continues to increase, as do investments in prophylactic and therapeutic indications. Explore a cost-model that compares all modalities.

  2. Applying High Throughput Processes To Optimize AAV Titers 3/8/2023

    A growing number of AAV product developers are recognizing the value in moving to suspension as early in development as possible in order to optimize production.

  3. Viral Safety Handbook 3/6/2023

    Since production templates depend on cell culture processes, biopharmaceuticals are susceptible to adventitious agent contamination. Explore a holistic overview of viral safety consolidating decades of expertise and process understanding.

  4. Chromatography Solutions For AAV Full And Empty Capsid Separation 3/1/2023

    Effective separation of full and empty AAV capsids requires implementation of purification strategies that differ from standard approaches used for traditional modalities. Explore two cases describing such approaches.

  5. Performing A Tangential Flow Filtration (TFF) Optimization Study 2/14/2023

    This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system and the Bio4C® Control Software.

  6. Implementing High Cell Density Cryopreservation In Your Seed Train 1/22/2023

    Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.

  7. Validation Master Plan For Filtration Systems Used In Aseptic Processing 1/13/2023

    Regulatory guidance provides a framework for aseptic processing that ensures patient safety. Learn about the best practices for validating performance of critical filtration systems used in aseptic processing.

  8. Capsules Versus Hollow Fibers For Ultrafiltration/Diafiltration (UF/DF) 1/13/2023

    Explore the performance evaluation of a first-of-its-kind spiral-wound TFF filter versus hollow fibers for UF/DF of viral vectors and the impact of either filter type on a TFF process.

  9. Biopharma 4.0: Convergence Of Information, Operations, And Processing Tech 1/7/2023

    Biomanufacturers seeking a place in a competitive and lucrative future must start engaging in change now to meet the demands for delivering drugs more quickly to the patients who need them.

  10. Using High Cell Density Cryopreservation For Seed Train Intensification 12/21/2022

    The traditional seed train expansion process can be time consuming. Learn how seed train intensification techniques such as high cell density cryopreservation (HCDC) can accelerate and streamline the process.