Featured Articles

71. 3D Cell Culture: From Academia To Big Pharma 12/22/2021

    While literature had long praised the promise of 3D, the industry uptake didn't accelerate until it became operationally feasible to produce 3D work at scale. Commercial tools and technologies that make 3D more accessible and less labor-intensive have helped make that happen.

72. Breast Cancer Microenvironments: Then, Now And Tomorrow 12/20/2021

    Researchers are keenly interested in studying cancer microenvironments because of their utility in understanding cancer progression. As cancer investigators continue to glean the reconstructive benefits of 3D models' in vivo-like contexts for their investigations, those learnings have yielded a better understanding of how — and why — 3D is superior to 2D when creating cancer microenvironments.

73. 3D Cell Culture And Drug Discovery 12/20/2021

    There is a significant need for new technologies that increase precision in drug discovery. Authentic 3D cell culture models are enhancing the drug discovery process by modeling in vivo conditions and microenvironments far more precisely, yielding results with better clinical outcomes.

74. Apply The Right Hydrogel In Your Microplates For Better 3D Cell Culture Research 12/19/2021

    With emerging innovations in bioprinting and adaptive bioengineering, the innovations just keep on growing, flooding the market with exciting new options to add to your lab's 3D cell culture toolkit. But which type of hydrogel is right for you?

75. 3D Cell Culture Applications And Bioprinting Will Change How We Research Cancers 12/19/2021

    Complex aspects of cancer like metastasis can be modeled and studied, and the efficacy and toxicity of drugs can be tested more realistically and rapidly with the advent of 3D cell culture applications and 3D bioprinting. Learn how 3D bioprinting works and how it is advancing cancer research.

76. How 3D Cultures Better Mimic In Vivo Conditions In The Field 12/16/2021

    Although the traditional 2D cell culture is still used as a primary experimental tool all across the world, we look into how 3D cultures better mimic in vivo conditions because they provide cells the physical environment they need to interact naturally.

77. In Vivo-like Cell Culture: The Impact Of 3-Dimensional Technologies On Your Cell-based Applications 12/14/2021

    The limitations of 2D cell culture can cause roadblocks to research and contribute to poor predictive power of preclinical cell-based drug and toxicity screening assays. In this article we explore several more reasons why 3D is better and provide tips for perfecting the technique for optimal results.

78. Bone Marrow-Derived Human Mesenchymal Stem Cell Production In HYPERStack® 36-layer Cell Culture Vessels 8/18/2021

    Although Mesenchymal stem cells (MSCs) can be isolated from different tissue sources, bone marrow-derived MSCs are commonly studied due to their ease of access and achievable therapeutic dosage (2 x 10⁶ cells/kb of body weight). Here, we demonstrate the utility of the Corning HYPERStack 36-layer cell culture vessel as a tool to meet the growing demand for expanding bone marrow-derived MSCs to relevant scale for clinical application workflows.

79. Corning® X-WASH® System For DMSO Reduction Of Cryopreserved Human Mesenchymal Stem Cells 8/18/2021

    Cryopreservation is a necessary part of workflows for both autologous and allogeneic therapies. Cryoprotectants, such as dimethyl sulphoxide (DMSO), are often added to freezing media in order to reduce ice formation and increase cell survival post-thaw. However, DMSO itself can be cytotoxic so it is necessary to reduce its final concentration as much as possible³. In this article, we demonstrate how the Corning X-WASH can reduce the amount of DMSO used in cryopreserved cells through a semi-automated, closed system.

80. Transfection Best Practices For AAV Gene Therapy Programs 8/17/2021

    As viral vectors continue to push gene therapy innovations closer to market, many researchers are setting their sights on optimizing the process of transfection — that is, the process of delivering corrective genetic material into cells. It's not just a question of how to transfect, but also how to do it efficiently and at a high volume. Approaches that may work for one cell line may not work for another, and all transfection protocols can have varying implications for scalability and cost during production for clinical trials. This article explores some best practices for transfection.