FEATURED ARTICLES

• The Power Of The Pool: Using Bulk Cultures For Clinical Trial Manufacturing

  Stable bulk cultures, made highly uniform using transposase-mediated technologies, may be the key to expediting clone selection for many biopharmaceutical applications.

• Stable Bulk Cultures: A Fast Path To Antibody Manufacturing

  The potential advantages that stable bulk cultures can offer a drug development paradigm are poised to accelerate and bolster biopharmaceutical clinical manufacturing.

• Leveraging AI And ML For Better Biologics

  For many bioprocessing applications, both artificial intelligence (AI) and machine learning (ML) can be used in every phase of development to support optimization and streamline repetitive, effort-intensive processes.

• The Value Of Tailoring Transposons For Optimized Biotherapeutic Production

  By leveraging transposase-mediated technologies together with transposon design to achieve semi-targeted integration, drug developers can more efficient and consistent biotherapeutic protein production.

• Using GPS Engineering To Optimize Antibody-Based Drug Development

  Explore the results collected when a platform designed with ML-guided GPS engineering was applied to develop a lead molecule targeting a mechanism in neuronal disease.

• Leveraging Transposase Technologies To Optimize Cell Line Development

  Enable a wide array of genomic manipulation with the more regulated and efficient genomic insertion that's made possible by transposase-based technologies.

• What You Paste Matters

  Explore the use of transposase/transposon systems in the biotech industry, particularly in the development of stable cell lines for protein manufacturing.

• Engineering CHO K1 Cells With Three Orthogonal Transposase Systems

  Transposase-mediated genome engineering enables the robust and stable relocation of discrete DNA segments (transposons) in the genome, providing a valuable tool for stable transgene expression.

• Obtain Proteins With Optimal Properties For Commercial Applications

  Tap into the vast diversity and potential of proteins found in nature using a unique protein platform based on Machine Learning and Design of Experiment.

• SAR – Sequence-Activity Relationships for Efficient Protein Engineering

  As protein-based therapeutics gain traction in the greater market, innovative techniques aimed at their optimization have become a key driver for industry.

• Codon Optimization for Recombinant Protein Expression

  Despite our lack of understanding of the mechanistic forces behind sequence design for increased recombinant protein expression yield, a better, more tailored codon optimization paradigm is achievable.

• Biotech Engineered To Meet Emergency Response Timelines

  Rapid antibody engineering and cell line development are vital in bringing therapies to clinics efficiently. Now, innovative technologies and communicative systems are making unrivaled speeds possible.

• Rapid Generation Of Bulk-Selected CHO Pools

  Traditional cell line development is extremely time-consuming, taking up to six months and delaying the runway to clinical trials. However, innovative transposase technology offers a fast and robust alternative.

• What Provided Critical Reagents To The COVID-19 Pandemic Response?

  Typically, mAb manufacturing takes up to 60 days due to demand and outsourcing lags. Instead, imagine a unified platform that can deliver your mAb in 18 days.

• Build Your Genome Engineering Toolbox For Success

  Fast, efficient, and precise options for genome engineering are rapidly infiltrating the marketplace – the key to success is identifying the mechanism and tool(s) best suited for your goals.