Cell Line Development For Multi-Chain Biologics: Leveraging The Leap In Transposase Platform

This webinar discusses the Leap-In Transpose Platform's application in creating Chinese Hamster Ovary (CHO) cell lines for manufacturing multi-chain biologics. The platform integrates features from the GPS Platform, which uses machine learning to engineer biological functions. The Leap-In Transpose Platform efficiently moves DNA while maintaining the structural integrity of transposons. This presentation emphasizes the uniformity of the generated pools in terms of titer and the rapid selection of these pools. It also focuses on a case study where the platform was used in a COVID-19 treatment, enabling the quick production of banked pools. Explore these demonstrations of the Leap-In platform's capabilities, the future considerations for 3-chain and 4-chain molecules including chain ratio balancing, and the platform's success in adjusting chain ratios to improve product quality and titer.