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| Webinar: Simplifying ADC Analysis: Real-Time DAR and Concentration Measurement Without Dilution | Unlock faster, safer ADC development with smarter analytics. This Repligen webinar reveals how variable pathlength spectroscopy delivers real-time, accurate DAR and concentration data without dilution. Explore case studies showing reduced variability, minimized handling of potent payloads, and streamlined workflows. Learn how PAT-driven insights enhance process control, accelerate scale-up, and replace traditional UV-Vis methods for more consistent, efficient manufacturing outcomes. Click here to learn more. |
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FOCUS ON UPSTREAM MANUFACTURING |
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By Ramakrishnan Natesan, Jenil Patel, Neeraj J. Agrawal — Process Development, Amgen Inc. | Dilution's effects on downstream processes and final formulation is often understated. A statistical framework can quantify measurement uncertainty's impacts. | |
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| Solutions For The Clinical-Grade Manufacturing | Webinar | Miltenyi Biotec | Explore the crucial role of NK cells in the immune system and learn efficient methodologies for manufacturing gene-engineered NK cells and scaling up production. |
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| Why Is Custom Cell Culture Media So Important? | Article | By Brad N. Taylor, Ph.D., Nucleus Biologics | Customizing cell culture media is an important part of the early stages of development considering its composition is crucial for cellular therapeutics' success |
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| Advanced Technology Platform For Stem Cell-Derived Exosomes | Poster | By Elie Zakhem, Jae Jung, Cameron Garland, et al., RoosterBio and Lauren Torres, Mario Sinani, Carl Breuning, et al., Repligen | Demand for EVs is rising due to their therapeutic promise. Examine two scalable platforms that address production challenges to support EVs' expanding clinical and commercial applications. |
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| Advancing Biologics Development With Next-Gen Cell Line Development | Article | By Woo Chi, Ph.D., Yingji Jin, Ph.D., and Jaeeun Kim, Samsung Biologics | Next-gen CLD utilizes transposase-mediated integration for speed and stability and employs an engineered cell line to enhance ADCC and a high-throughput assay for early glycosylation control. |
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| Rev-Up AAV Genome Production In Upstream Manufacturing | Application Note | By Becky Reese, Jennifer Swanson, Austin Storck, et al., Mirus Bio | By increasing recombinant AAV titers, this AAV enhancer can help reduce upstream manufacturing costs and lower the cost per therapeutic dose. |
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UPSTREAM MANUFACTURING SOLUTIONS |
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| Connect With Bioprocess Online: |
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