Newsletter | August 31, 2026

08.31.26 -- Understanding Modality-Specific Development Challenges

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The body as a bioreactor

What if therapeutic production could move from the facility into the patient? Explore how advances in lipid nanoparticle design, delivery science, and manufacturing are helping bring the body-as-a-bioreactor vision closer to reality—and reshaping what may be possible for genomic medicine.

FOCUS ON UPSTREAM MANUFACTURING

Understanding Modality-Specific Development Challenges

Vaccines have different developmental challenges than cancer therapeutics, which can have different challenges than gene therapies. In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists share some of the common friction points across their respective modalities as it relates to process development. 

 

 

Applying The Lessons From mAbs Production To Advanced Therapeutics

Continuous bioprocessing is revolutionizing manufacturing. Gain expert insights about cutting-edge innovations in monoclonal antibody production that enable scalable solutions for next-gen therapies.

 

Enabling Clinical-Grade Automated Manufacturing Of γδ T Cells

Explore smarter approaches to γδ T cell manufacturing, including scalable expansion, efficient transduction, and streamlined analytics, as well as how to build workflows that support validation.

 

Mammalian Or Microbial? Choosing The Right Expression System

Whether you’re trying to achieve speed and cost-effectiveness or higher yields and glycosylation capabilities, discover how the right system can be tailored to meet the needs of each unique biologic.

 

Strain Engineering And Process Development

Microbial expression systems using automated parallel screening can accelerate therapeutic protein development by improving yield and quality from early-stage production.

 

What You Paste Matters

Read more about the use of transposase/transposon systems in the biotech industry, particularly in the development of stable cell lines for protein manufacturing.

 

Cell Collection Basics For The Transplant And CGT Industries

Breakthroughs in CAR T-cell and stem cell therapies depend on mastering cellular collection. Understanding these fundamentals is vital for advancing treatment efficacy and patient outcomes.

 

Talent, Infrastructure, And Support To Drive Drug Development

Middlesex County, NJ, offers life sciences organizations a deep talent pool, an extensive R&D presence, and dedicated backing by local government investment.

 

A Practical Framework For Scaling Post-Fermentation

Evaluate the technical suitability and implementation of simultaneous galactosylation and sialylation across early downstream intermediates to streamline routine manufacturing.

 

Novel Engineered Plasmids, Optimized HEK293 Cell Line For AAV Productivity

See how we have further improved the platform process with the creation of engineered plasmids that afford significantly higher titers and productivity levels compared to standard systems.

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Webinar: Improving Clinical Translation for ADCs and Immuno-Oncology with Human-Relevant Tumor Models

Learn how patient-derived tumor organoids can serve as human-relevant models for evaluating antibody-drug conjugates (ADCs) and immuno-oncology therapies. Through modality-specific case studies, discover how these models provide efficacy and mechanistic insights. Explore how matched clinical and genomic data can enhance interpretation of drug responses, support biomarker exploration, and improve confidence in translational decision-making throughout oncology drug development.

UPSTREAM MANUFACTURING SOLUTIONS

An Enhanced Feed For Evolving mAb Process Platforms - FUJIFILM Biosciences

Large-Scale Lentivirus Manufacturing With A Transfection Complex Stabilizer - Mirus Bio

A Prime Expression Medium For High-Density HEK293 Growth - Cytiva

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